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22232 Amiodarone (AMIO)

Amiodarone (AMIO)
Test Code: AMIOSO
Synonyms/Keywords

Cordarone​, Desethylamiodarone, Pacerone

Useful For

Monitoring Amiodarone therapy, especially when amiodarone is coadministered with other drugs that may interact

Evaluation of possible amiodarone toxicity

Assessment of patient compliance​

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ 1.5 mL​ 0.5 mL​
Collection Processing Instructions
Draw blood no sooner than 12 hours (trough value) after last dose or immediately before next scheduled dose.  Centrifuge within 2 hours of draw and aliquot to remove serum from spun RBCs. 
Specimen Stability Information
Specimen Type Temperature Time
Serum ​​ ​ Refrigerated (preferred) 28 days​
Frozen 28 days
​Room Temperature ​24 hours
Rejection Criteria
​Serum separator tube (SST)
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Labs Monday through Saturday 2 days Liquid Chromatography Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
Mayo Medical Labs

Amiodarone:

Trough Value

Therapeutic concentration: 0.5-2.0 mcg/mL​

Toxic concentration: >2.5 mcg/mL

Desethylamiodarone:

No therapeutic range established; activity and serum concentration are similar to parent drug.

Interpretation
Clinical effects generally require serum concentrations >0.5 mcg/mL. Increased risk of toxicity is associated with amiodarone concentrations >2.5 mcg/mL. Although therapeutic and toxic ranges are based only on the parent drug, the active metabolite N-desethylamiodarone should be present in similar concentrations to amiodarone.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80299 ​ ​ ​ ​
Synonyms/Keywords

Cordarone​, Desethylamiodarone, Pacerone

Ordering Applications
Ordering Application Description
​Centricity ​Amiodarone-incl. desethylamiodarone
​Cerner ​Amiodarone Level
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT)​ 1.5 mL​ 0.5 mL​
Collection Processing
Draw blood no sooner than 12 hours (trough value) after last dose or immediately before next scheduled dose.  Centrifuge within 2 hours of draw and aliquot to remove serum from spun RBCs. 
Specimen Stability Information
Specimen Type Temperature Time
Serum ​​ ​ Refrigerated (preferred) 28 days​
Frozen 28 days
​Room Temperature ​24 hours
Rejection Criteria
​Serum separator tube (SST)
Useful For

Monitoring Amiodarone therapy, especially when amiodarone is coadministered with other drugs that may interact

Evaluation of possible amiodarone toxicity

Assessment of patient compliance​

Reference Range Information
Performing Location Reference Range
Mayo Medical Labs

Amiodarone:

Trough Value

Therapeutic concentration: 0.5-2.0 mcg/mL​

Toxic concentration: >2.5 mcg/mL

Desethylamiodarone:

No therapeutic range established; activity and serum concentration are similar to parent drug.

Interpretation
Clinical effects generally require serum concentrations >0.5 mcg/mL. Increased risk of toxicity is associated with amiodarone concentrations >2.5 mcg/mL. Although therapeutic and toxic ranges are based only on the parent drug, the active metabolite N-desethylamiodarone should be present in similar concentrations to amiodarone.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Labs Monday through Saturday 2 days Liquid Chromatography Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80299 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.