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22338 Arylsulfatase A, Leukocytes (ARSAW)

Arylsulfatase A, Leukocytes (ARSAW)
Test Code: MISC
Synonyms/Keywords
​Ref Lab Code: 8779, ARSA Deficiency, ARYLSULFATASE A (WBC), Arylsulfatase A Deficiency, Metachromatic Leukodystrophy, MLD, WBC Aryl Sulfatase A
Useful For
​Detection of metachromatic leukodystrophy
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Whole blood Yellow Top (ACD solution B)​ Yellow Top (ACD solution A)​ 7 mL​ 5 mL​ ​
Collection Processing Instructions

​Specimen must arrive within 48 hours of draw to be stabilized. Draw specimen Monday through Thursday only and not the day before a holiday. Specimen should be drawn and packaged as close to shipping time as possible.

Do not transfer blood to other containers.

Specimen Stability Information
Specimen Type Temperature Time
Whole blood​ ​ Refrigerated (preferred)​ 48 hours​
Ambient ​ 48 hours​
Rejection Criteria
Gross hemolysis
Specimen >48 hours old​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
Specimens are processed Monday through Sunday.
Assay is performed Thursday​
8 days​
Colorimetric Enzyme Assay​
Reference Lab
Mayo Clinic Laboratories
Test Information
​Results from this assay may not reflect carrier status because of individual variation of arylsulfatase A enzyme levels.
Reference Range Information
​> or =62 nmol/h/mg
Interpretation
​Decreased enzyme levels indicate an individual is affected with metachromatic leukodystrophy (MLD). Note that individuals with pseudoarylsulfatase A deficiency can have results in this range, but are otherwise unaffected with MLD.
 
Abnormal results should be confirmed using ARSU/8777 Arylsulfatase A, Urine. If molecular confirmation is desired, consider molecular genetic testing of the ARSA gene.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82657 ​ ​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 8779, ARSA Deficiency, ARYLSULFATASE A (WBC), Arylsulfatase A Deficiency, Metachromatic Leukodystrophy, MLD, WBC Aryl Sulfatase A
Ordering Applications
Ordering Application Description
​COM ​Misc Test
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Whole blood Yellow Top (ACD solution B)​ Yellow Top (ACD solution A)​ 7 mL​ 5 mL​ ​
Collection Processing

​Specimen must arrive within 48 hours of draw to be stabilized. Draw specimen Monday through Thursday only and not the day before a holiday. Specimen should be drawn and packaged as close to shipping time as possible.

Do not transfer blood to other containers.

Specimen Stability Information
Specimen Type Temperature Time
Whole blood​ ​ Refrigerated (preferred)​ 48 hours​
Ambient ​ 48 hours​
Rejection Criteria
Gross hemolysis
Specimen >48 hours old​
Useful For
​Detection of metachromatic leukodystrophy
Reference Range Information
​> or =62 nmol/h/mg
Interpretation
​Decreased enzyme levels indicate an individual is affected with metachromatic leukodystrophy (MLD). Note that individuals with pseudoarylsulfatase A deficiency can have results in this range, but are otherwise unaffected with MLD.
 
Abnormal results should be confirmed using ARSU/8777 Arylsulfatase A, Urine. If molecular confirmation is desired, consider molecular genetic testing of the ARSA gene.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
Specimens are processed Monday through Sunday.
Assay is performed Thursday​
8 days​
Colorimetric Enzyme Assay​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82657 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.