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22348 Beta-2 Microglobulin, Urine (B2MU)

Beta-2 Microglobulin, Urine (B2MU)
Test Code: B2MRUSO
Synonyms/Keywords
B2M, (Beta-2 Microglobulin) m Urine, Beta 2 Microglobulin Test, Beta-2 Microglobulin, Urine
Test Components
​Creatinine, Beta-2-Microglobulin, Beta-2-Microglobulin/Creatinine Ratio, pH
Useful For
​Evaluation of renal tubular damage
 
Monitoring exposure to cadmium and mercury
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Urine Plastic, 10-mL urine tube ​ ​Sterile Container 3 mL​ 1  mL​ ​
Collection Processing Instructions

1. Patient should empty bladder.
2. Have patient drink at least 0.5 liters of water.
3. Within 1 hour, collect a random urine specimen.
4. Transfer 3 mL from a well-mixed random collection to plastic, 10-mL urine tube (Supply T068).

If pH is greater than 8, lower pH to 6 - 8 by adding 1M HCL. If pH less than 6, increase pH to 6 - 8 by adding 5% NaOH. Titrate with appropriate preservative until pH of 6 - 8 has been reached. Record the pH on the transport tube.

Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ Frozen (preferred)​ 60 days​
Refrigerated ​ 48 hours​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories forwards to ARUP Labs​
 Sunday through Saturday
1 day​
Quantitative Chemiluminescent Immunoassay​
Reference Lab
Mayo Clinic Laboratories
Test Information
​Beta-2-microglobulin is a low-molecular-weight protein that forms the light chain component of class I histocompatibility (HLA [human leukocyte antigen]) antigens. Increased urine levels are seen in proximal tubular renal damage due to a variety of causes, including cadmiun, mercury, lithium, or aminoglycoside toxicity pyelonephritis; and Balkan nephropathy, a chronic interstitial nephritis of unknown etiology. Beta-2-microglobulin excretion is increased 100 to 1,000 times normal levels in cadmium-exposed workers.
Reference Range Information
Beta-2-Microglobulin, Urine : 0 - 300 g/L
Beta-2-Microglobulin, ratio to CRT: 0 - 300 g/g CRT
Interpretation
​Increased excretion is consistent with renal tubular damage.
 
Beta-2-microglobulin excretion is increased 100 to 1,000 times normal levels in cadmium-exposed workers.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82232​ ​ ​ Beta-2 microglobulin​ ​
Synonyms/Keywords
B2M, (Beta-2 Microglobulin) m Urine, Beta 2 Microglobulin Test, Beta-2 Microglobulin, Urine
Test Components
​Creatinine, Beta-2-Microglobulin, Beta-2-Microglobulin/Creatinine Ratio, pH
Ordering Applications
Ordering Application Description
​Centricity ​Beta-2 Microglobulin (300243)
​Cerner ​Beta 2 Microglobulin Urine (300245)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Urine Plastic, 10-mL urine tube ​ ​Sterile Container 3 mL​ 1  mL​ ​
Collection Processing

1. Patient should empty bladder.
2. Have patient drink at least 0.5 liters of water.
3. Within 1 hour, collect a random urine specimen.
4. Transfer 3 mL from a well-mixed random collection to plastic, 10-mL urine tube (Supply T068).

If pH is greater than 8, lower pH to 6 - 8 by adding 1M HCL. If pH less than 6, increase pH to 6 - 8 by adding 5% NaOH. Titrate with appropriate preservative until pH of 6 - 8 has been reached. Record the pH on the transport tube.

Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ Frozen (preferred)​ 60 days​
Refrigerated ​ 48 hours​
Useful For
​Evaluation of renal tubular damage
 
Monitoring exposure to cadmium and mercury
Test Components
​Creatinine, Beta-2-Microglobulin, Beta-2-Microglobulin/Creatinine Ratio, pH
Reference Range Information
Beta-2-Microglobulin, Urine : 0 - 300 g/L
Beta-2-Microglobulin, ratio to CRT: 0 - 300 g/g CRT
Interpretation
​Increased excretion is consistent with renal tubular damage.
 
Beta-2-microglobulin excretion is increased 100 to 1,000 times normal levels in cadmium-exposed workers.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories forwards to ARUP Labs​
 Sunday through Saturday
1 day​
Quantitative Chemiluminescent Immunoassay​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82232​ ​ ​ Beta-2 microglobulin​ ​
For most current information refer to the Marshfield Laboratory online reference manual.