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22556 Deoxycorticosteroids (DOC)

Deoxycorticosteroids (DOC)
Test Code: MISC
Synonyms/Keywords
​Lab Ref Code:  8547, 11-Deoxycorticosteroid, 11-Deoxycortisol, 11-Desoxycortisol, Compound B, Compound S, Corticosterone, Deoxycortisol, Tetrahydro S
Useful For
Diagnostic workup of patients with congenital adrenal hyperplasia.
Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency.
Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top tube (RTT) ​Serum Separator Tube (SST) ​0.3 mL ​0.25 mL ​
Collection Processing Instructions
Morning (8 a.m.) specimen is preferred.
Additional Information: Indicate if specimen was drawn before or after metyrapone
Specimen Stability Information
Specimen Type Temperature Time
​Serum Refrigerated (preferred)​ 7 days​
​ ​Frozen ​14 days
Rejection Criteria
Hemolysis
Mild OK; Gross reject
​Lipemia
Mild reject; Gross reject
​Icterus
Mild OK; Gross OK
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​​
Tuesday; 2 p.m.
​		 3 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​​
< or =18 years: <344 ng/dL
>18 years: 10-79 ng/dL
Interpretation
​
In a patient suspected of having CAH, elevated serum 11-deoxycortisol levels indicate possible 11 beta-hydroxylase deficiency. However, not all patients will show baseline elevations in serum 11-deoxycortisol levels. In a significant proportion of cases, increases in 11-deoxycortisol levels are only apparent after ACTH(1-24) stimulation.(1)
 
Serum 11-deoxycortisol levels <1,700 ng/dL 8 hours after metyrapone administration is indicative of probable adrenal insufficiency. The test cannot reliably distinguish between primary and secondary or tertiary causes of adrenal failure, as neither patients with pituitary failure, nor those with primary adrenocortical failure, tend to show an increase of 11-deoxycortisol levels after metyrapone is administered.
 
See Steroid Pathways in Special Instructions.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82634 ​ ​ ​ ​
Synonyms/Keywords
​Lab Ref Code:  8547, 11-Deoxycorticosteroid, 11-Deoxycortisol, 11-Desoxycortisol, Compound B, Compound S, Corticosterone, Deoxycortisol, Tetrahydro S
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top tube (RTT) ​Serum Separator Tube (SST) ​0.3 mL ​0.25 mL ​
Collection Processing
Morning (8 a.m.) specimen is preferred.
Additional Information: Indicate if specimen was drawn before or after metyrapone
Specimen Stability Information
Specimen Type Temperature Time
​Serum Refrigerated (preferred)​ 7 days​
​ ​Frozen ​14 days
Rejection Criteria
Hemolysis
Mild OK; Gross reject
​Lipemia
Mild reject; Gross reject
​Icterus
Mild OK; Gross OK
Useful For
Diagnostic workup of patients with congenital adrenal hyperplasia.
Part of metyrapone testing in the workup of suspected secondary or tertiary adrenal insufficiency.
Part of metyrapone testing in the differential diagnostic workup of Cushing syndrome.
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​​
< or =18 years: <344 ng/dL
>18 years: 10-79 ng/dL
Interpretation
​
In a patient suspected of having CAH, elevated serum 11-deoxycortisol levels indicate possible 11 beta-hydroxylase deficiency. However, not all patients will show baseline elevations in serum 11-deoxycortisol levels. In a significant proportion of cases, increases in 11-deoxycortisol levels are only apparent after ACTH(1-24) stimulation.(1)
 
Serum 11-deoxycortisol levels <1,700 ng/dL 8 hours after metyrapone administration is indicative of probable adrenal insufficiency. The test cannot reliably distinguish between primary and secondary or tertiary causes of adrenal failure, as neither patients with pituitary failure, nor those with primary adrenocortical failure, tend to show an increase of 11-deoxycortisol levels after metyrapone is administered.
 
See Steroid Pathways in Special Instructions.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​​
Tuesday; 2 p.m.
​		 3 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82634 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.