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22561 Diazepam and Nordiazepam (DIA)

Diazepam and Nordiazepam (DIA)
Test Code: DIAZSO
Synonyms/Keywords
​Lab Ref Code:  8629, Benzodiazepines, Clorazepate (Tranxene), Diazepam & Nordiazepam S, Diazepam (Valium), Nordiazepam (Tranxene), Tranxene (Clorazepate), Valium (Diazepam)
Useful For
Assessing compliance
Monitoring for appropriate therapeutic level
Assessing toxicity
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top tube (RTT) ​ 1 mL ​0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum Refrigerated (preferred)​ ​14 days
​ ​Ambient ​14 days
​ ​Frozen ​14 days
Rejection Criteria
Hemolysis
Mild OK; Gross reject
​Lipemia
Mild OK; Gross reject
​Icterus
Mild OK; Gross reject
​Other ​Serum gel tube
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​​
Thursday; 9:00 a.m.
​		 2 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Reference Range
Therapeutic concentrations
 
Diazepam and Nordiazepam: 200-2,500 ng/mL
​
Interpretation
For seizures:
Serum concentrations are not usually monitored during early therapy because response to the drug can be monitored clinically as seizure control. If seizures resume despite adequate therapy, another anticonvulsant must be considered.
 
For antianxiety and other uses:
-Therapeutic concentrations of diazepam are 0.2 to 0.8 mcg/mL
-After a normal dose of diazepam, tranxene, or prazepam, nordiazepam concentrations range from 0.4 to 1.2 mcg/mL
-Sedation occurs when the total benzodiazepine concentration is >2.5 mcg/mL
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80346 ​ ​ ​ ​
Synonyms/Keywords
​Lab Ref Code:  8629, Benzodiazepines, Clorazepate (Tranxene), Diazepam & Nordiazepam S, Diazepam (Valium), Nordiazepam (Tranxene), Tranxene (Clorazepate), Valium (Diazepam)
Ordering Applications
Ordering Application Description
​Centricity ​Diazepam
​Cerner ​Diazepam and Nordiazepam Level (8629)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top tube (RTT) ​ 1 mL ​0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum Refrigerated (preferred)​ ​14 days
​ ​Ambient ​14 days
​ ​Frozen ​14 days
Rejection Criteria
Hemolysis
Mild OK; Gross reject
​Lipemia
Mild OK; Gross reject
​Icterus
Mild OK; Gross reject
​Other ​Serum gel tube
Useful For
Assessing compliance
Monitoring for appropriate therapeutic level
Assessing toxicity
Reference Range Information
Reference Range
Therapeutic concentrations
 
Diazepam and Nordiazepam: 200-2,500 ng/mL
​
Interpretation
For seizures:
Serum concentrations are not usually monitored during early therapy because response to the drug can be monitored clinically as seizure control. If seizures resume despite adequate therapy, another anticonvulsant must be considered.
 
For antianxiety and other uses:
-Therapeutic concentrations of diazepam are 0.2 to 0.8 mcg/mL
-After a normal dose of diazepam, tranxene, or prazepam, nordiazepam concentrations range from 0.4 to 1.2 mcg/mL
-Sedation occurs when the total benzodiazepine concentration is >2.5 mcg/mL
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​​
Thursday; 9:00 a.m.
​		 2 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80346 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.