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22714 Hepatitis Be Antigen and Antibody (HEAG)

Hepatitis Be Antigen and Antibody (HEAG)
Test Code: HEP-BE
Synonyms/Keywords
​Ref Lab Code: 8311, Hepatitis Be Profile, Serum, HEPBE Profile, Serum
Useful For
​Determining infectivity of hepatitis B virus (HBV) carriers
 
Monitoring infection status of chronically HBV-infected patients
 
Monitoring serologic response of chronically HBV-infected patients receiving antiviral therapy
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Serum Separator Tube (SST)​ ​ 1.5 mL​ 1.0 mL​ ​
Collection Processing Instructions

​Spin down and immediately remove serum from clot.  Submit sample in a plastic vial.

Additional Information:
1. Date of draw is required.
2. If ordered with QHBV/82416 Hepatitis B Virus DNA Quantification by bDNA, Serum or HBVQU/88634 Hepatitis B Virus DNA Detection and Quantification by Real-Time PCR, Serum; send separate vials.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Frozen (preferred)​ ​
​ Refrigerated ​ 7 days​
​ Ambient ​ 24 hours​
Rejection Criteria
Gross hemolysis
​Gross lipemia
​Gross icterus
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
Monday through Saturday​
1 day​
Chemiluminescence Immunoassay (CIA)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
​Negative. (Interpretation depends on clinical setting.)
Interpretation
​Presence of hepatitis Be (HBe) antigen and absence of HBe antibody usually indicate active hepatitis B virus (HBV) replication and high infectivity.
 
Absence of HBe antigen with appearance of HBe antibody is consistent with loss of HBV infectivity.
 
Although resolution of chronic HBV infection generally follows appearance of HBe antibody, the HBV carrier state may persist.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86707​ ​ ​ Hepatitis Be antibody​ ​
87350​ ​ ​ Hepatitis Be antigen​ ​
Synonyms/Keywords
​Ref Lab Code: 8311, Hepatitis Be Profile, Serum, HEPBE Profile, Serum
Ordering Applications
Ordering Application Description
​Centricity ​Hep. Be Ag. & Ab.
​Cerner None​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Serum Separator Tube (SST)​ ​ 1.5 mL​ 1.0 mL​ ​
Collection Processing

​Spin down and immediately remove serum from clot.  Submit sample in a plastic vial.

Additional Information:
1. Date of draw is required.
2. If ordered with QHBV/82416 Hepatitis B Virus DNA Quantification by bDNA, Serum or HBVQU/88634 Hepatitis B Virus DNA Detection and Quantification by Real-Time PCR, Serum; send separate vials.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Frozen (preferred)​ ​
​ Refrigerated ​ 7 days​
​ Ambient ​ 24 hours​
Rejection Criteria
Gross hemolysis
​Gross lipemia
​Gross icterus
Useful For
​Determining infectivity of hepatitis B virus (HBV) carriers
 
Monitoring infection status of chronically HBV-infected patients
 
Monitoring serologic response of chronically HBV-infected patients receiving antiviral therapy
Reference Range Information
​Negative. (Interpretation depends on clinical setting.)
Interpretation
​Presence of hepatitis Be (HBe) antigen and absence of HBe antibody usually indicate active hepatitis B virus (HBV) replication and high infectivity.
 
Absence of HBe antigen with appearance of HBe antibody is consistent with loss of HBV infectivity.
 
Although resolution of chronic HBV infection generally follows appearance of HBe antibody, the HBV carrier state may persist.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
Monday through Saturday​
1 day​
Chemiluminescence Immunoassay (CIA)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86707​ ​ ​ Hepatitis Be antibody​ ​
87350​ ​ ​ Hepatitis Be antigen​ ​
For most current information refer to the Marshfield Laboratory online reference manual.