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22804 Iron, Urine (FEU)

Iron, Urine (FEU)
Test Code: MISC
Synonyms/Keywords
​Ref Lab Code: 8571, Fe (Iron), Iron (Fe)
Useful For
​Diagnosis of hemochromatosis, hemolytic anemia, paroxysmal nocturnal hemoglobinemia, and impaired biliary clearance
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Urine Clean, plastic urine container with no metal cap or glued insert​ ​ 10 mL​ 0.5 mL​ ​
Collection Processing Instructions
​1. Collect urine for 24 hours.
2. No preservative.
3. See Metals Analysis-Collection and Transport in Special Instructions for complete instructions.
Trace Metals Analysis - Specimen Collection and Transport
4. Refrigerate specimen within 4 hours of completion of 24-hour collection.
Submit sample in a plastic, 10-mL urine tube or a clean, plastic aliquot container with no metal cap or glued insert.
 
Additional Information:
1. 24-Hour volume is required.
2. See Urine Preservatives in Special Instructions for multiple collections.
Urine Preservative Cross-Reference Information
3. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerated (preferred)​ 7 days​
​ Frozen ​ 7 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Wednesday, Friday​
1 day​
Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
0-15 years: not established
> or =16 years: 100-300 mcg/specimen
Interpretation
​Normal excretion of iron occurs at the rate of approximately 100 mcg/day to 300 mcg/day. In the event that dietary iron is below minimum daily requirements (<2 mg/day in females, <1 mg/day in males), urinary excretion will be less than normal.
 
Urinary iron is greater than normal in iron overload. It is not uncommon to observe iron excretion >20,000 mcg/day in a patient with clinically evident hemochromatosis. Daily urine output of iron ranging from 500 mcg to 5,000 mcg suggests active hemolytic anemia, early-stage hemochromatosis, or impaired biliary clearance.
 
Because iron elimination undergoes extreme diurnal variation (serum levels 10 times higher in a.m. than p.m.), collection of random specimens can cause very misleading interpretation.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83540 ​ ​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 8571, Fe (Iron), Iron (Fe)
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Urine Clean, plastic urine container with no metal cap or glued insert​ ​ 10 mL​ 0.5 mL​ ​
Collection Processing
​1. Collect urine for 24 hours.
2. No preservative.
3. See Metals Analysis-Collection and Transport in Special Instructions for complete instructions.
Trace Metals Analysis - Specimen Collection and Transport
4. Refrigerate specimen within 4 hours of completion of 24-hour collection.
Submit sample in a plastic, 10-mL urine tube or a clean, plastic aliquot container with no metal cap or glued insert.
 
Additional Information:
1. 24-Hour volume is required.
2. See Urine Preservatives in Special Instructions for multiple collections.
Urine Preservative Cross-Reference Information
3. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerated (preferred)​ 7 days​
​ Frozen ​ 7 days​
Useful For
​Diagnosis of hemochromatosis, hemolytic anemia, paroxysmal nocturnal hemoglobinemia, and impaired biliary clearance
Reference Range Information
0-15 years: not established
> or =16 years: 100-300 mcg/specimen
Interpretation
​Normal excretion of iron occurs at the rate of approximately 100 mcg/day to 300 mcg/day. In the event that dietary iron is below minimum daily requirements (<2 mg/day in females, <1 mg/day in males), urinary excretion will be less than normal.
 
Urinary iron is greater than normal in iron overload. It is not uncommon to observe iron excretion >20,000 mcg/day in a patient with clinically evident hemochromatosis. Daily urine output of iron ranging from 500 mcg to 5,000 mcg suggests active hemolytic anemia, early-stage hemochromatosis, or impaired biliary clearance.
 
Because iron elimination undergoes extreme diurnal variation (serum levels 10 times higher in a.m. than p.m.), collection of random specimens can cause very misleading interpretation.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Wednesday, Friday​
1 day​
Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83540 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.