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22821 Lead Profile Occupational, Exposure, Blood (PBZP)

Lead Profile Occupational, Exposure, Blood (PBZP)
Test Code: BLOSHSO
Synonyms/Keywords
Lead (Pb), Exposure
Test Components
Lead, Zinc Protoporphyrin (ZPP)​
Useful For
Detecting lead toxicity and monitoring treatment
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole Blood​ Royal Blue Top BD Vacutainer Plus with EDTA blood collection tube ​Royal Blue Top Tube (RBTT) Monoject trace element collection tube conatining EDTA anticoagulant​ 2 mL​ ​0.5 mL ​
Collection Processing Instructions

Send specimen in original tube.

Special Instructions and Forms:

Lead/Heavy Metals Reporting Form

Trace Metals Analysis - Specimen Collection and Transport

Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood Refrigerated​ 14 days​
Rejection Criteria
Gross Hemolysis
Gross Lipemia
Clotted specimen  
​Heparin
Interference
​High concentrations of gadolinium and iodine are known to interfere with test.  If contrast media containing gadolinium or iodine has been administered specimen should not be collected for 96 hours.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​​
Monday through Friday
17:00
 1 day

Lead (PBB): Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) 

ZPPB:  Hematofluorometry​

Reference Lab
Mayo Clinic Laboratories
Test Information
 
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​​
LEAD
All ages: 0.0-4.9 mcg/dL
Critical values:
Pediatrics (<=15 years): > or = 20.0 mcg/dL
Adults (>=16 years): > or = 70.0 mcg/dL
 
ZINC PROTOPORPHYRIN
<100 mcg/dL
Interpretation
The Centers for Disease Control and Prevention (CDC) has identified the blood lead test as the preferred test for detecting lead exposure in children. Chronic whole blood lead levels <10 mcg/dL is often seen in children. For pediatric patients, there may be an association with blood lead values of 5 mcg/dL to 9 mcg/dL and adverse health effects. Follow up testing in 3 to 6 months may be warranted. Chelation therapy is indicated when whole blood lead concentration is >45 mcg/dL.
 
The Occupational Safety and Health Administration (OSHA) has published the following standards for employees working in industry:
 
-Employees with whole blood lead >60 mcg/dL must be removed from workplace exposure.
-Employees with whole blood lead >50 mcg/dL averaged over 3 blood samplings must be removed from workplace exposure.
-An employee may not return to work in a lead exposure environment until whole blood lead is <40 mcg/dL.
 
An elevated erythrocyte protoporphyrin (EP) indicates impairment of the heme biosynthetic pathway. Elevated EP levels in adults may indicate long-term lead exposure. Expected EP levels seen in heavy metal toxicity are in the range of >100 mcg/dL.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83655 ​ ​1 ​Lead ​
​84202 ​ 1​ Zinc Protoporphyrin, Blood ​
Synonyms/Keywords
Lead (Pb), Exposure
Test Components
Lead, Zinc Protoporphyrin (ZPP)​
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole Blood​ Royal Blue Top BD Vacutainer Plus with EDTA blood collection tube ​Royal Blue Top Tube (RBTT) Monoject trace element collection tube conatining EDTA anticoagulant​ 2 mL​ ​0.5 mL ​
Collection Processing

Send specimen in original tube.

Special Instructions and Forms:

Lead/Heavy Metals Reporting Form

Trace Metals Analysis - Specimen Collection and Transport

Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood Refrigerated​ 14 days​
Rejection Criteria
Gross Hemolysis
Gross Lipemia
Clotted specimen  
​Heparin
Interference
​High concentrations of gadolinium and iodine are known to interfere with test.  If contrast media containing gadolinium or iodine has been administered specimen should not be collected for 96 hours.
Useful For
Detecting lead toxicity and monitoring treatment
Test Components
Lead, Zinc Protoporphyrin (ZPP)​
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​​
LEAD
All ages: 0.0-4.9 mcg/dL
Critical values:
Pediatrics (<=15 years): > or = 20.0 mcg/dL
Adults (>=16 years): > or = 70.0 mcg/dL
 
ZINC PROTOPORPHYRIN
<100 mcg/dL
Interpretation
The Centers for Disease Control and Prevention (CDC) has identified the blood lead test as the preferred test for detecting lead exposure in children. Chronic whole blood lead levels <10 mcg/dL is often seen in children. For pediatric patients, there may be an association with blood lead values of 5 mcg/dL to 9 mcg/dL and adverse health effects. Follow up testing in 3 to 6 months may be warranted. Chelation therapy is indicated when whole blood lead concentration is >45 mcg/dL.
 
The Occupational Safety and Health Administration (OSHA) has published the following standards for employees working in industry:
 
-Employees with whole blood lead >60 mcg/dL must be removed from workplace exposure.
-Employees with whole blood lead >50 mcg/dL averaged over 3 blood samplings must be removed from workplace exposure.
-An employee may not return to work in a lead exposure environment until whole blood lead is <40 mcg/dL.
 
An elevated erythrocyte protoporphyrin (EP) indicates impairment of the heme biosynthetic pathway. Elevated EP levels in adults may indicate long-term lead exposure. Expected EP levels seen in heavy metal toxicity are in the range of >100 mcg/dL.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​​
Monday through Friday
17:00
 1 day

Lead (PBB): Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) 

ZPPB:  Hematofluorometry​

Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83655 ​ ​1 ​Lead ​
​84202 ​ 1​ Zinc Protoporphyrin, Blood ​
For most current information refer to the Marshfield Laboratory online reference manual.