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22841 Lupus Anticoagulant Panel

Lupus Anticoagulant Panel
Test Code: LAPAN
Synonyms/Keywords
Lupus Inhibitor Work-up, Lupus Inhibitor Panel​
Test Components
Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA)​
Useful For
​Recommended for the evaluation of patients with thrombosis and/or prolonged phospholipid-dependent clotting assays (ex: PT and APTT).  This panel is not recommended to aid in the diagnosis of Systemic Lupus Erythematosis (SLE), see ANA EIA (ANA HEp-2 Serum Screen).
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ Two 0.75 mL aliquots​ 0.75 mL​ 0.5 mL ​
Collection Processing Instructions
​Two 0.75 mL citrated Blue Top Tube (BTT) plasma aliquots.
If more than one coagulation test is ordered, a separate aliquot is needed for each test.
-Collect in Citrated Blue Top Tube (BTT)
-Citrate anticoagulant must be adjusted for HCT >55%
-Tubes must be at least 90% full
-Invert completely 3-4 times (without shaking) to mix
*See Instructions for:  Preparation of Platelet Poor Plasma
Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday, Wednesday, Friday ​Less than 2 hours Optical clot detection/Siemens BCSXP​
Test Information
The detection of a lupus anticoagulant, a heterogeneous group of antibodies, is enhanced by performing two or more screening tests.  Therefore, the LUPUS ANTICOAGULANT PANEL includes both a DRVVT and PTTLA.  If results of either or both tests are positive for LA, a lupus anticoagulant is present.  Platelet poor plasma plasma platelet count must be less than 10,000/uL.  Test results may be falsely negative due to the presence of excess platelets in the plasma.​
 
Requested panel includes Lupus anticoagulant testing (DRVVT and PTT-LA), these tests should not be performed on patients receiving rivaroxaban, apixaban, dabigatran, edoxaban, or warfarin.  For patients on these medications, order the anticardiolipin antibody and/or anti-beta-2 glycoprotein 1 antibody tests individually instead of the panel.
Reference Range Information
Performing Location Reference Range
​Marshfield ​See individual test listings for reference ranges.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​85613 ​ ​ Russell viper venom time, diluted​ ​
​85732 ​ ​ Thromboplastin substitution, each fraction​ ​
Synonyms/Keywords
Lupus Inhibitor Work-up, Lupus Inhibitor Panel​
Test Components
Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA)​
Ordering Applications
Ordering Application Description
​Centricity ​Lupus Anticoag Panel
​Cerner ​Lupus Anticoagulant Panel
​COM ​Lupus Anticoagulant Panel
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ Two 0.75 mL aliquots​ 0.75 mL​ 0.5 mL ​
Collection Processing
​Two 0.75 mL citrated Blue Top Tube (BTT) plasma aliquots.
If more than one coagulation test is ordered, a separate aliquot is needed for each test.
-Collect in Citrated Blue Top Tube (BTT)
-Citrate anticoagulant must be adjusted for HCT >55%
-Tubes must be at least 90% full
-Invert completely 3-4 times (without shaking) to mix
*See Instructions for:  Preparation of Platelet Poor Plasma
Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Useful For
​Recommended for the evaluation of patients with thrombosis and/or prolonged phospholipid-dependent clotting assays (ex: PT and APTT).  This panel is not recommended to aid in the diagnosis of Systemic Lupus Erythematosis (SLE), see ANA EIA (ANA HEp-2 Serum Screen).
Test Components
Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA)​
Reference Range Information
Performing Location Reference Range
​Marshfield ​See individual test listings for reference ranges.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday, Wednesday, Friday ​Less than 2 hours Optical clot detection/Siemens BCSXP​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​85613 ​ ​ Russell viper venom time, diluted​ ​
​85732 ​ ​ Thromboplastin substitution, each fraction​ ​
For most current information refer to the Marshfield Laboratory online reference manual.