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22872 Metanephrines, Urine 24 Hour

Metanephrines, Urine 24 Hour
Test Code: MET
Synonyms/Keywords
Metanephrine, Normetanephrine; Metanephrine Fractionatio​
Test Components
24 hour Urine Metanephrine, Normetanephrine and Creatinine​
Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Biochemical Evaluation and Diagnosis of Catecholamine-producing Tumors

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ 24 hr urine jug with 7 g sulfamic acid preservative​
24 hr urine jug with 20 mL 6N HCl or
25 mL 33% acetic acid​
 10 mL aliquot from a well mixed 24 hr urine​ 5 mL aliquot​ 5 mL aliquot​
Collection Processing Instructions
Indicate collection dates and times.  Total volume must be measured, recorded and included with the test request.  Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerate​ 2 weeks​
Rejection Criteria
Specimens that are improperly preserved
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Marshfield​

Tuesday, Thursday​

Samples must be in the performing department by 8am on the day of testing for results the same day

6-8 hours​UPLC-MS MS (Waters TQ-S system)
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 50-840 ug/24 hr

Metanephrine: 0-370 ug/24 hr

Reference ranges are based on hypertensive population results​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
​
Synonyms/Keywords
Metanephrine, Normetanephrine; Metanephrine Fractionatio​
Test Components
24 hour Urine Metanephrine, Normetanephrine and Creatinine​
Ordering Applications
Ordering Application Description
​Centricity ​Metanephrine-24Hr ur
​Cerner ​Metanephrines 24 Hour Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ 24 hr urine jug with 7 g sulfamic acid preservative​
24 hr urine jug with 20 mL 6N HCl or
25 mL 33% acetic acid​
 10 mL aliquot from a well mixed 24 hr urine​ 5 mL aliquot​ 5 mL aliquot​
Collection Processing
Indicate collection dates and times.  Total volume must be measured, recorded and included with the test request.  Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerate​ 2 weeks​
Rejection Criteria
Specimens that are improperly preserved
Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Biochemical Evaluation and Diagnosis of Catecholamine-producing Tumors

Test Components
24 hour Urine Metanephrine, Normetanephrine and Creatinine​
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 50-840 ug/24 hr

Metanephrine: 0-370 ug/24 hr

Reference ranges are based on hypertensive population results​

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Marshfield​

Tuesday, Thursday​

Samples must be in the performing department by 8am on the day of testing for results the same day

6-8 hours​UPLC-MS MS (Waters TQ-S system)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
​
For most current information refer to the Marshfield Laboratory online reference manual.