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23188 First Trimester Screen

First Trimester Screen
Test Code: FTSNTSO
Synonyms/Keywords
​NTD First Trimester
Test Components
​This test consists of a combination of an ultrasound of the fluid behind the neck of the fetus (nuchal translucency) and a blood test performed between 11 weeks, 1 day and 13 weeks, 6 days of pregnancy. The blood test can be performed as early as 9 weeks, 0 days of pregnancy, however, maximum timing for ultrasound is when fetus has a crown rump length or 45-84 mm.
Analysis of the blood sample is for free Beta HCG and PAPP-A. A specific risk for Down and Trisomy-18 is then calculated based on the patient's age, nuchal translucency measurement, free Beta HCG and PAPP-A.
Useful For
​This test is a prenatal screen for specific risk for Down Syndrome (91% detection rate), Trisomy-18 (98% detection rate) and other chromosomal abnormalities.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Whole Blood Fingerstick from mother utilizing filter card provided by NTD Laboratories ​ ​ ​ ​
Collection Processing Instructions

​Fingerstick from mother utilizing filter card provided by NTD Laboratories.  Phone number for supplies is 888-683-5227. 

A patient ultra sound is NOT required for the first trimester screen to be completed.

Specimen Stability Information
Specimen Type Temperature
​Whole blood on filter card ​Ambient
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
NTD Laboratories​ ​Monday through Friday ​3 days ​Chemiluminescent Immunoassay
Reference Lab
NTD Laboratories
Test Information
​The ultrasound examination confirms the fetus' gestational age and measures the nuchal translucency (NT), or the fluid accumulation behind the fetus' neck. These combined biochemical and biophysical markers yield the most sensitive screening results possible at the earliest point during the pregnancy, achieving a 91% detection rate at a 5% false positive rate for Down syndrome (and a 95% detection rate at a 0.3% false positive for trisomy 18 and 13). When a Fetal Nasal Bone Assessment is added to the protocol, the detection rate for Down syndrome increases to 95% at a false positive rate of just 2%.
Reference Range Information
Performing Location Reference Range
​NTD Laboratories ​Interpretive Report
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82105 ​ ​1 Alpha-fetoprotein, sera ​
​84163 ​1 ​Pregnancy-associated plasma protein (PAPP-A) ​
​84704 ​ ​1 ​hCG, free beta chain ​
Synonyms/Keywords
​NTD First Trimester
Test Components
​This test consists of a combination of an ultrasound of the fluid behind the neck of the fetus (nuchal translucency) and a blood test performed between 11 weeks, 1 day and 13 weeks, 6 days of pregnancy. The blood test can be performed as early as 9 weeks, 0 days of pregnancy, however, maximum timing for ultrasound is when fetus has a crown rump length or 45-84 mm.
Analysis of the blood sample is for free Beta HCG and PAPP-A. A specific risk for Down and Trisomy-18 is then calculated based on the patient's age, nuchal translucency measurement, free Beta HCG and PAPP-A.
Ordering Applications
Ordering Application Description
​Centricity ​First Trimester Screen with NTP
​Cerner ​First Trimester Screen
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Whole Blood Fingerstick from mother utilizing filter card provided by NTD Laboratories ​ ​ ​ ​
Collection Processing

​Fingerstick from mother utilizing filter card provided by NTD Laboratories.  Phone number for supplies is 888-683-5227. 

A patient ultra sound is NOT required for the first trimester screen to be completed.

Specimen Stability Information
Specimen Type Temperature
​Whole blood on filter card ​Ambient
Useful For
​This test is a prenatal screen for specific risk for Down Syndrome (91% detection rate), Trisomy-18 (98% detection rate) and other chromosomal abnormalities.
Test Components
​This test consists of a combination of an ultrasound of the fluid behind the neck of the fetus (nuchal translucency) and a blood test performed between 11 weeks, 1 day and 13 weeks, 6 days of pregnancy. The blood test can be performed as early as 9 weeks, 0 days of pregnancy, however, maximum timing for ultrasound is when fetus has a crown rump length or 45-84 mm.
Analysis of the blood sample is for free Beta HCG and PAPP-A. A specific risk for Down and Trisomy-18 is then calculated based on the patient's age, nuchal translucency measurement, free Beta HCG and PAPP-A.
Reference Range Information
Performing Location Reference Range
​NTD Laboratories ​Interpretive Report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
NTD Laboratories​ ​Monday through Friday ​3 days ​Chemiluminescent Immunoassay
Reference Lab
NTD Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82105 ​ ​1 Alpha-fetoprotein, sera ​
​84163 ​1 ​Pregnancy-associated plasma protein (PAPP-A) ​
​84704 ​ ​1 ​hCG, free beta chain ​
For most current information refer to the Marshfield Laboratory online reference manual.