23267 Mumps Virus Antibody, IgM (MMPM)

Mumps virus, together with parainfluenza types 1 through 4, respiratory syncytial virus, and measles virus are classified in the family Paramyxovirdae. Mumps is an acute infection which causes the painful enlargement of the salivary glands in approximately 70% to 90% of children (4-15 years of age) who develop clinical Disease.(2) In 5% to 20% of postpubertal individuals, testicular pain (orchitis in males) and abdominal pain (oophoritis in females) can occur. Other complications include pancreatitis (<5% of cases) and central nervous system disease (meningitis/encephalitis) that occur rarely (about 1 in 6,000 cases of mumps). Widespread routine immunization of infants with attenuated mumps virus has changed the epidemiology of this virus infection. Since 1989,  there has been a steady decline in reported mumps cases, with and average of 265 cases each year since 2001. However, a recent outbreak of mumps in 2006 re-emphasized that this virus continued to persist in the population, and laboratory testing may be needed in clinically compatible situations.

 

The laboratory diagnosis of mumps is typically accomplished by detection of antibody to mumps virus. However, due to the limitations of serology (eg, inadequate sensitivity and specificity), additional laboratory testing including virus isolation or detection of viral nucleic acid by PCR in throat, saliva or urine specimens should be considered in clinically compatible situations.

Negative (reported as positive, equivocal, or negative)

Index value 0.00-0.79=negative

Positive:  presence of IgM-class antibodies to mumps virus may support a clinical diagnosis of recent/acute phase infection with this virus.

 

Negative:  absence of IgM-class antibodies to mumps virus suggests lack of acute phase infection with mumps virus. However, serology my be negative in early disease, and results should be interpreted in the context of clinical findings.