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24807 Haemophilus influenzae Type B Antibody, IgG (HIBS)

Haemophilus influenzae Type B Antibody, IgG (HIBS)
Test Code: HAEABSO
Synonyms/Keywords
​Ref Lab Code: 83261, H. influenzae Antibody, Haemophilus influenzae B Vaccine Response, HIB (Haemophilus influenzae Type B) Vaccine Response
Useful For
Assessing a patient's immunological (IgG) response to Haemophilus influenzae type B (HIB) vaccine
 
Assessing immunity against HIB
 
As an aid in the evaluation of immunodeficiency
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL ​0.4 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Refrigerated (preferred) ​7 days
​ ​Frozen ​7 days
Rejection Criteria
Hemolysis Mild OK; Gross reject
​Lipemia Mild OK; Gross reject​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Tuesday, Thursday​ ​Same day/1 day
Enzyme Immunoassay (EIA)​
Reference Lab
Mayo Clinic Laboratories
Test Information
Haemophilus influenzae type B (HIB) is an encapsulated gram-negative cocco-bacillary bacterium that can cause devastating disease in young children including meningitis, bacteremia, cellulitis, epiglottitis, pneumonia, and septic arthritis.
 
One of the great advances in modern medicine has been the development of an effective vaccine against HIB. A patient's immunological response to HIB vaccine can be determined by measuring anti-HIB IgG antibody using this enzyme immunoassay (EIA) technique.
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​>=0.15 mg/L
Interpretation
An anti-Haemophilus influenzae type B (HIB) IgG antibody concentration of 0.15 mg/L is generally accepted as the minimum level for protection at a given time, however, it does not confer long-term protection. A study from Finland suggested that the optimum protective level is 1.0 mg/L postimmunization.(2) Furthermore, studies have shown that the response to HIB vaccine is age-related.
 
By testing pre- and postvaccination patient serum specimens, this test may be used to aid diagnosis of immunodeficiency.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86684 ​ ​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 83261, H. influenzae Antibody, Haemophilus influenzae B Vaccine Response, HIB (Haemophilus influenzae Type B) Vaccine Response
Ordering Applications
Ordering Application Description
​Centricity ​H. influ Type B Ab, IgG (83261)
​Cerner None​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​0.5 mL ​0.4 mL ​
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Refrigerated (preferred) ​7 days
​ ​Frozen ​7 days
Rejection Criteria
Hemolysis Mild OK; Gross reject
​Lipemia Mild OK; Gross reject​
Useful For
Assessing a patient's immunological (IgG) response to Haemophilus influenzae type B (HIB) vaccine
 
Assessing immunity against HIB
 
As an aid in the evaluation of immunodeficiency
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​>=0.15 mg/L
Interpretation
An anti-Haemophilus influenzae type B (HIB) IgG antibody concentration of 0.15 mg/L is generally accepted as the minimum level for protection at a given time, however, it does not confer long-term protection. A study from Finland suggested that the optimum protective level is 1.0 mg/L postimmunization.(2) Furthermore, studies have shown that the response to HIB vaccine is age-related.
 
By testing pre- and postvaccination patient serum specimens, this test may be used to aid diagnosis of immunodeficiency.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Tuesday, Thursday​ ​Same day/1 day
Enzyme Immunoassay (EIA)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86684 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.