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24887 Levetiracetam, Serum

Levetiracetam, Serum
Test Code: LEVE
Synonyms/Keywords
Keppra, Leviteracetam​
Useful For
This test is useful for monitoring leviteracetam (anticonvulsant) levels.  Leviteracetam is approved for adjunctive therapy in the treatment of partial onset seizures in adults and children, 4 years or older, with epilepsy​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube
(RTT)​
 0.5 mL ​ 0.5 mL 0.3 mL
Collection Processing Instructions
​Specimens collected in serum separator tube (SST) will be rejected.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Ambient​ 48 hours​
Refrigerate​ 2 weeks​
Frozen 3 months​
Rejection Criteria
​Specimens collected in a serum or plasma separator tube
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday, Wednesday, Friday​ 6-8 hours​ ​​UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System​
Samples must be in performing department by 8am on day of testing for results the same day.​ ​ ​ ​
Testing may be batched and set up on alternative days of the week as needed.
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
Reference Range Information
Performing Location Reference Range
Marshfield​

Peak concentration: 10-63 ug/mL

Trough concentration: 3-34 ug/mL

Critical value: See critical value list of current critical values​

Interpretation
​Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80177 ​ ​ ​ ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
​
Synonyms/Keywords
Keppra, Leviteracetam​
Ordering Applications
Ordering Application Description
​Centricity ​Levetiracetam, Serum
​Cerner ​Levetiracetam Level
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​
Red Top Tube
(RTT)​
 0.5 mL ​ 0.5 mL 0.3 mL
Collection Processing
​Specimens collected in serum separator tube (SST) will be rejected.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Ambient​ 48 hours​
Refrigerate​ 2 weeks​
Frozen 3 months​
Rejection Criteria
​Specimens collected in a serum or plasma separator tube
Useful For
This test is useful for monitoring leviteracetam (anticonvulsant) levels.  Leviteracetam is approved for adjunctive therapy in the treatment of partial onset seizures in adults and children, 4 years or older, with epilepsy​
Reference Range Information
Performing Location Reference Range
Marshfield​

Peak concentration: 10-63 ug/mL

Trough concentration: 3-34 ug/mL

Critical value: See critical value list of current critical values​

Interpretation
​Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday, Wednesday, Friday​ 6-8 hours​ ​​UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System​
Samples must be in performing department by 8am on day of testing for results the same day.​ ​ ​ ​
Testing may be batched and set up on alternative days of the week as needed.
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80177 ​ ​ ​ ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
​
For most current information refer to the Marshfield Laboratory online reference manual.