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25090 Amphetamines, Urine, Confirm Only by LCMS/MS

Amphetamines, Urine, Confirm Only by LCMS/MS
Test Code: CO-AMP
Synonyms/Keywords
Amphetamine, Methamphetamine, MDMA, Ecstasy, MDA, Adderall, Speed, Phentermine, Ephedrine, Pseudoephedrine, Desoxyn, Crystal Meth, methylenedioxymethamphetamine, methylenedioxyamphetamine​, amines, MDEA, Vyvanse
Useful For
Detecting exposure to amphetamines to monitor compliance in taking prescribed medication or to detect abuse​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​
Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.​
 
This test is a LCMS/MS confirmation only for the amphetamines drug class. It is intended for use only in patients where an initial drug screening test has already been performed at the time of specimen collection (i.e. Point-of-Care drug screening cup, dipstick, etc.). The specimen will not be screened by immunoassay in the laboratory; it will only be tested by LCMS/MS. If an initial drug screen has not been performed at the specimen collection site, it is more appropriate to order the "Amphetamines, Urine" (AMP) test code which includes an initial screen. The test will detect the presence of amphetamine, phentermine, methamphetamine, ephedrine, pseudoephedrine, MDA, MDEA and MDMA (Ecstasy).
 
The Amphetamine drug group includes a variety of drugs of abuse, diet aids, and vasoconstrictor/decongestants found in OTC cold preparations.
Reference Range Information
Performing Location Reference Range
Marshfield​

Negative.  Positives are reported with a quantitative LCMS/MS (phentermine, ephedrine and pseudoephedrine are reported with a qualitative LCMS/MS).

Interpretation
Methamphetamine metabolizes to amphetamine, therefore both can be present after use of methamphetamine.
 
The approximate detection time of amphetamines in urine is between 1-3 days after last use.​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80326 ​ 1​ ​Amphetamine Confirmation by LCMS/MS ​
80359​ ​ ​1 ​Methylenedioxyamphetamines (MDA, MDMA, and MDEA) ​
​G0480 ​ ​1 ​Amphetamine/Methamphetamine Confirmation by LCMS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.​
Synonyms/Keywords
Amphetamine, Methamphetamine, MDMA, Ecstasy, MDA, Adderall, Speed, Phentermine, Ephedrine, Pseudoephedrine, Desoxyn, Crystal Meth, methylenedioxymethamphetamine, methylenedioxyamphetamine​, amines, MDEA, Vyvanse
Ordering Applications
Ordering Application Description
​Centricity ​Amphetamine, Urine, Confirm Only by GCMS
​Cerner ​Amphetamine, Urine, Confirm Only
​COM ​Amphetamines, Urine, Confirm
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Useful For
Detecting exposure to amphetamines to monitor compliance in taking prescribed medication or to detect abuse​
Reference Range Information
Performing Location Reference Range
Marshfield​

Negative.  Positives are reported with a quantitative LCMS/MS (phentermine, ephedrine and pseudoephedrine are reported with a qualitative LCMS/MS).

Interpretation
Methamphetamine metabolizes to amphetamine, therefore both can be present after use of methamphetamine.
 
The approximate detection time of amphetamines in urine is between 1-3 days after last use.​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​
Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80326 ​ 1​ ​Amphetamine Confirmation by LCMS/MS ​
80359​ ​ ​1 ​Methylenedioxyamphetamines (MDA, MDMA, and MDEA) ​
​G0480 ​ ​1 ​Amphetamine/Methamphetamine Confirmation by LCMS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.​
For most current information refer to the Marshfield Laboratory online reference manual.