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25097 Oxycodone, Urine, Confirm Only by GCMS

Oxycodone, Urine, Confirm Only by GCMS
Test Code: CO-OXY
Synonyms/Keywords
​Oxycodone, Oxymorphone, Oxycontin, Percodan, Percocet, Opana
Useful For
Detecting exposure to oxycodone and/or oxmorphone to monitor compliance in taking prescribed medications or to detect abuse.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days
Frozen​ 30 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​ Gas chromatography-mass spectrometry (GCMS) using selected ion monitoring​
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
 
This test is a screen for the Oxycodone drug method group (i.e. only the drugs detected in the single oxycodone assay performed at Marshfield Labs: oxycodone and oxymorphone) by immunoassay; if the screen is positive, this test automatically includes GCMS confirmation for oxycodone and oxymorphone. Quantitation/confirmation charged separately if needed. It is intended for use only in patients where an initial drug screening test has not already been performed (i.e. Point-of-Care drug screening cup, dipstick, etc.).
 
Oxycodone and oxymorphone are opiods (semisynthetic narcotic analgesics derived from the compound thebane which occurs naturally in opium). Oxycodone is available in many preparations for oral use including Percodan, Percocet, and Oxycontin. Oxycodone is partially metabolized in the body to oxymorphone. Oxymorphone is also available in an oral preparation to treat chronic pain. ​
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative.  Positives are reported with a quantitative GCMS result.​
Interpretation

Current Cutoff Levels for Toxicology

1. Oxycodone metabolizes to oxymorphone.
2. Hydrocodone can be a pharmaceutical impurity of the Oxycodone production process.  It may be present in very small amounts with high levels of Oxycodone (less than 4% of the oxycodone level).
3. Oxycodone and Hydromorphone can be pharmaceutical impurities of the Oxymorphone production process.  If either are present at levels less than or equal to 0.5% of the Oxymorphone level, it is likely an impurity and not evidence of use of Oxycodone and/or Hydromorphone.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80365 ​ ​1 Oxycodone Confirmation by GCMS
​G0480 ​ ​1 ​Oxycodone Confirmation by GCMS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
​
Synonyms/Keywords
​Oxycodone, Oxymorphone, Oxycontin, Percodan, Percocet, Opana
Ordering Applications
Ordering Application Description
​Centricity ​Oxycodone, Urine, Confirm Only by GCMS
​Cerner ​Oxycodone, Urine, Confirm Only
​COM ​Oxycodone, Urine, Confirm
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days
Frozen​ 30 days​
Useful For
Detecting exposure to oxycodone and/or oxmorphone to monitor compliance in taking prescribed medications or to detect abuse.
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative.  Positives are reported with a quantitative GCMS result.​
Interpretation

Current Cutoff Levels for Toxicology

1. Oxycodone metabolizes to oxymorphone.
2. Hydrocodone can be a pharmaceutical impurity of the Oxycodone production process.  It may be present in very small amounts with high levels of Oxycodone (less than 4% of the oxycodone level).
3. Oxycodone and Hydromorphone can be pharmaceutical impurities of the Oxymorphone production process.  If either are present at levels less than or equal to 0.5% of the Oxymorphone level, it is likely an impurity and not evidence of use of Oxycodone and/or Hydromorphone.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​ Gas chromatography-mass spectrometry (GCMS) using selected ion monitoring​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80365 ​ ​1 Oxycodone Confirmation by GCMS
​G0480 ​ ​1 ​Oxycodone Confirmation by GCMS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
​
For most current information refer to the Marshfield Laboratory online reference manual.