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25204 Islet Ag 2 (IA-2) Antibody (IA2)

Islet Ag 2 (IA-2) Antibody (IA2)
Test Code: IA2SO
Synonyms/Keywords
​Iset Cell Antbody, ICA-512, Anti-IA2 Antibodies
Useful For

Clinical distinction of type 1 from type 2 diabetes mellitus

Identification of individuals at risk of type 1 diabetes (including high-risk relatives of patiens with diabetes)

Prediction of future need for insulin treatment in adult-onset diabetic patients

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1.5 mL ​1.0 mL ​
Specimen Stability Information
Specimen Type Temperature ​Time
​Serum ​ ​ ​Refrigerate ​28 days
​Ambient ​72 hours
​Frozen ​28 days
Rejection Criteria
Grossly hemolyzed, lipemic and icteric samples
Interference
​Negative results do not exclude the diagnosis of or future risk for type 1 diabetes mellitus. The risk of developing type 1 diabetes may be stratified further by testing for: 1) antibodies targeting insulin, glutamic acid decarboxylase, and zinc transporter 8 (ZnT8) and 2) HLA genetic markers. Careful monitoring of hyperglycemia is the mainstay of determining the requirement for insulin therapy.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Tuesday and Friday ​3 days/negative, 5 days/positive ​Radioimmunoassay (RIA)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​Negative
Interpretation
​Seropositivity for IA-2 autoantibody (> 0.02 nmol/L) is supportive of:
-A diagnosis of type 1 diabetes
-A high risk for future development of diabetes
-A current or future need for insulin therapy in patients with diabetes
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86341 ​ ​ ​ ​
Synonyms/Keywords
​Iset Cell Antbody, ICA-512, Anti-IA2 Antibodies
Ordering Applications
Ordering Application Description
​Centricity ​Islet Antigen 2(IA-2) Antibody (IA2)
​Cerner ​None
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1.5 mL ​1.0 mL ​
Specimen Stability Information
Specimen Type Temperature ​Time
​Serum ​ ​ ​Refrigerate ​28 days
​Ambient ​72 hours
​Frozen ​28 days
Rejection Criteria
Grossly hemolyzed, lipemic and icteric samples
Interference
​Negative results do not exclude the diagnosis of or future risk for type 1 diabetes mellitus. The risk of developing type 1 diabetes may be stratified further by testing for: 1) antibodies targeting insulin, glutamic acid decarboxylase, and zinc transporter 8 (ZnT8) and 2) HLA genetic markers. Careful monitoring of hyperglycemia is the mainstay of determining the requirement for insulin therapy.
Useful For

Clinical distinction of type 1 from type 2 diabetes mellitus

Identification of individuals at risk of type 1 diabetes (including high-risk relatives of patiens with diabetes)

Prediction of future need for insulin treatment in adult-onset diabetic patients

Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​Negative
Interpretation
​Seropositivity for IA-2 autoantibody (> 0.02 nmol/L) is supportive of:
-A diagnosis of type 1 diabetes
-A high risk for future development of diabetes
-A current or future need for insulin therapy in patients with diabetes
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Tuesday and Friday ​3 days/negative, 5 days/positive ​Radioimmunoassay (RIA)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86341 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.