Allergen, Mushroom, IgE (MUSH)

Test Code: ALMSHSO

Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding

Synonyms/Keywords

Agaricus bisporus, Agaricus hortensis, Buttom Mushroom, Champignon, Common Mushroom, Cultivated Mushroom, Table Mushroom, White Mushroom,

Useful For

Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease and to define the allergens responsible for eliciting signs and symptoms.

Testing also may be useful to identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens.

Specimen Requirements

Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
Serum	Red Top Tube (RTT)	Serum Separator Tube (SST)	0.5 mL for each 5 allergens requested	For more than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL dead space

Collection Processing Instructions

Designate specific allergens from the list in Allergens-IgE Antibodies in Special Instructions.

Forms: If not ordering electronically, complete, print, and send an Allergen Test Request Form (T236) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/allergen-test-request-form.pdf).

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Refrigerated (preferred)	14 days
Serum	Frozen	90 days

Interference

Some individuals with clinically insignificant sensitivity to allergens may have measureable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

False-positive resuts for IgE antibodies may occur in patients with markedly elevated serum IgE (.2,500 kU/L) due to nonspecific binding to allergen solid phases.

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Analytical Time	Methodology/Instrumentation
Mayo Medical Laboratories	Monday through Friday	Same day/1 day	Fluorescence Enzyme Immunoassay (FEIA)

Reference Lab

Mayo Clinic Laboratories

Test Information

This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.

Reference Range Information

Performing Location

Reference Range

Mayo Medical Laboratories

Class	IgE kU/L	Interpretation
0	<0.35	Negative
1	0.35-0.69	Equivocal
2	0.70-3.49	Positive
3	3.50-17.4	Positive
4	17.5-49.9	Strongly positive
5	50.0-99.9	Strongly positive
6	> or =100	Strongly positive

Reference values apply to all ages

Interpretation

Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.

The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
86003		1	Allergen specific IgE quan/semiquan each allergen

Classification

Synonyms/Keywords

Agaricus bisporus, Agaricus hortensis, Buttom Mushroom, Champignon, Common Mushroom, Cultivated Mushroom, Table Mushroom, White Mushroom,

Ordering Applications

Ordering Application	Description

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.