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26009 Estrone, Serum (E1)

Estrone, Serum (E1)
Test Code: E1SO
Synonyms/Keywords
​E1 (Estrone)
Estrone (E1), Serum
Useful For
As part of the diagnosis and work-up of precocious and delayed puberty in females, and, to a lesser degree, males. As part of the diagnosis and work-up of suspected disorders of sex steroid metabolism, eg, aromatase deficiency and 17 alpha-hydroxylase deficiency. As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men. Monitoring low-dose female hormone replacement therapy in post-menopausal women. Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy).
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Red Top Tube (RTT) ​ ​1.2 mL ​0.8 mL ​
Collection Processing Instructions
Serum must be separated from red blood cells within 2 hours of draw.  
Specimens collected in a serum gel tube will not be accepted for testing. 
Specimen Stability Information
Specimen Type Temperature Time
​Serum Red ​ ​ ​Refrigerate (preferred) ​28 days
​Frozen ​28 days
​Ambient ​28 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Saturday ​2 days ​Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​
CHILDREN*
1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
Tanner Stages#
Mean Age
Reference Range
Stage I (>14 days and prepubertal)
7.1 years
Undetectable-16 pg/mL
Stage II
11.5 years
Undetectable-22 pg/mL
Stage III
13.6 years
10-25 pg/mL
Stage IV
15.1 years
10-46 pg/mL
Stage V
18 years
10-60 pg/mL
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
 
Females
Tanner Stages#
Mean Age
Reference Range
Stage I (>14 days and prepubertal)
7.1 years
Undetectable-29 pg/mL
Stage II
10.5 years
10-33 pg/mL
Stage III
11.6 years
15-43 pg/mL
Stage IV
12.3 years
16-77 pg/mL
Stage V
14.5 years
17-200 pg/mL
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
 
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
 
ADULTS
Males: 10-60 pg/mL
Females
Premenopausal: 17-200 pg/mL
Postmenopausal: 7-40 pg/mL
Conversion factor
E1: pg/mL x 3.704=pmol/L (molecular weight=270)
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82679 ​ ​1 ​ ​
Synonyms/Keywords
​E1 (Estrone)
Estrone (E1), Serum
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum ​Red Top Tube (RTT) ​ ​1.2 mL ​0.8 mL ​
Collection Processing
Serum must be separated from red blood cells within 2 hours of draw.  
Specimens collected in a serum gel tube will not be accepted for testing. 
Specimen Stability Information
Specimen Type Temperature Time
​Serum Red ​ ​ ​Refrigerate (preferred) ​28 days
​Frozen ​28 days
​Ambient ​28 days
Useful For
As part of the diagnosis and work-up of precocious and delayed puberty in females, and, to a lesser degree, males. As part of the diagnosis and work-up of suspected disorders of sex steroid metabolism, eg, aromatase deficiency and 17 alpha-hydroxylase deficiency. As an adjunct to clinical assessment, imaging studies and bone mineral density measurement in the fracture risk assessment of postmenopausal women, and, to a lesser degree, older men. Monitoring low-dose female hormone replacement therapy in post-menopausal women. Monitoring antiestrogen therapy (eg, aromatase inhibitor therapy).
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​
CHILDREN*
1-14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
Tanner Stages#
Mean Age
Reference Range
Stage I (>14 days and prepubertal)
7.1 years
Undetectable-16 pg/mL
Stage II
11.5 years
Undetectable-22 pg/mL
Stage III
13.6 years
10-25 pg/mL
Stage IV
15.1 years
10-46 pg/mL
Stage V
18 years
10-60 pg/mL
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (+/- 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
 
Females
Tanner Stages#
Mean Age
Reference Range
Stage I (>14 days and prepubertal)
7.1 years
Undetectable-29 pg/mL
Stage II
10.5 years
10-33 pg/mL
Stage III
11.6 years
15-43 pg/mL
Stage IV
12.3 years
16-77 pg/mL
Stage V
14.5 years
17-200 pg/mL
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (+/- 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
 
*The reference ranges for children are based on the published literature(1,2), cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
 
ADULTS
Males: 10-60 pg/mL
Females
Premenopausal: 17-200 pg/mL
Postmenopausal: 7-40 pg/mL
Conversion factor
E1: pg/mL x 3.704=pmol/L (molecular weight=270)
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday through Saturday ​2 days ​Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82679 ​ ​1 ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.