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Lab Test Reference Manual
Human Reference Manual
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26047
Lab Test Reference Manual
Human Reference Manual
Currently selected
26047
Alpha-1-Antitrypsin Proteotype S/Z by LC-MS/MS, Serum (A1ALC)
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Site Contents
Alpha-1-Antitrypsin Proteotype S/Z by LC-MS/MS, Serum (A1ALC)
Test Code: A1ALCSO
Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding
Synonyms/Keywords
Synonyms, Keywords
a-1-Antitrypsin, Proteotype
A1A Proteotyping
AAT Proteotyping
Alpha 1 Antitrypsin
Alpha-1-Antitrypsin by MS
Anti-Alpha-1-Trypsin
Antitrypsin
Antitrypsin, Proteotyping
Pi Typing (Alpha-1-Antitrypsin Proteotyping)
Protease Inhibitor Allo Typing
Test Components
Test Components
A1AT Proteotype S/Z, LC-MS/MS
Alpha-1-Antitrypsin, S
If the mass spectrometry proteotype and quantitative serum level are discordant, then phenotyping will be added and performed at an additional charge.
Useful For
Useful For
Determining the specific proteotype for prognosis and genetic counseling for patients with alpha-1-antitrypsin deficiency
Specimen Requirements
Specimen Requirements
Fasting Required
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No
Serum
Red Top Tube (RTT)
Serum Separator Tube (SST)
1.25 mL
0.5 mL
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Serum
Ambient
28 days
Refrigerate (preferred)
28 days
Frozen
28 days
Rejection Criteria
Rejection Criteria
Gross lipemia
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Mayo Medical Laboratories
Monday and Thursday; 12 pm
7 days
A1ASZ: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
AATP: Nephelometry
A1APR: Isoelectric Focusing
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Mayo Medical Laboratories
ALPHA-1-ANTITRYPSIN
100-190 mg/dL
ALPHA-1-ANTITRYPSIN PROTEOTYPE
Negative for S and Z phenotype (Non S Non Z)
Interpretation
Interpretations
For each of the possible alpha-1-antitrypsin (A1A) genotypes there is an expected range for the total serum level of A1A. However, a number of factors can influence either the A1A serum level or the A1A proteotype results, including acute illness (A1A is an acute-phase reactant), protein replacement therapy, the presence of other rare variants, or the presence of DNA polymorphisms. When the serum level differs from what is expected for that proteotype (ie, discordant), additional studies are performed to ensure the most appropriate interpretation of test results. Additional follow-up may include A1A phenotyping by isoelectric focusing, obtaining additional clinical information, and DNA sequencing.
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
82103
1
82542
1
82104
1
If needed
Synonyms/Keywords
Synonyms, Keywords
a-1-Antitrypsin, Proteotype
A1A Proteotyping
AAT Proteotyping
Alpha 1 Antitrypsin
Alpha-1-Antitrypsin by MS
Anti-Alpha-1-Trypsin
Antitrypsin
Antitrypsin, Proteotyping
Pi Typing (Alpha-1-Antitrypsin Proteotyping)
Protease Inhibitor Allo Typing
Test Components
Test Components
A1AT Proteotype S/Z, LC-MS/MS
Alpha-1-Antitrypsin, S
If the mass spectrometry proteotype and quantitative serum level are discordant, then phenotyping will be added and performed at an additional charge.
Ordering Applications
Ordering Applications
Ordering Application
Description
COM
Alpha 1 Antitrypsin Proteotype S/Z, Serum (A1ALC)
Centricity
Alpha 1 Antitrypsin Proteotype S/Z, Serum (A1ALC)
Cerner
Alpha 1 Antitrypsin Proteotype S/Z, Serum (A1ALC)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Requirements
Fasting Required
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No
Serum
Red Top Tube (RTT)
Serum Separator Tube (SST)
1.25 mL
0.5 mL
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Serum
Ambient
28 days
Refrigerate (preferred)
28 days
Frozen
28 days
Rejection Criteria
Rejection Criteria
Gross lipemia
Useful For
Useful For
Determining the specific proteotype for prognosis and genetic counseling for patients with alpha-1-antitrypsin deficiency
Test Components
Test Components
A1AT Proteotype S/Z, LC-MS/MS
Alpha-1-Antitrypsin, S
If the mass spectrometry proteotype and quantitative serum level are discordant, then phenotyping will be added and performed at an additional charge.
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Mayo Medical Laboratories
ALPHA-1-ANTITRYPSIN
100-190 mg/dL
ALPHA-1-ANTITRYPSIN PROTEOTYPE
Negative for S and Z phenotype (Non S Non Z)
Interpretation
Interpretations
For each of the possible alpha-1-antitrypsin (A1A) genotypes there is an expected range for the total serum level of A1A. However, a number of factors can influence either the A1A serum level or the A1A proteotype results, including acute illness (A1A is an acute-phase reactant), protein replacement therapy, the presence of other rare variants, or the presence of DNA polymorphisms. When the serum level differs from what is expected for that proteotype (ie, discordant), additional studies are performed to ensure the most appropriate interpretation of test results. Additional follow-up may include A1A phenotyping by isoelectric focusing, obtaining additional clinical information, and DNA sequencing.
For more information visit:
http://labtestsonline.org
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Mayo Medical Laboratories
Monday and Thursday; 12 pm
7 days
A1ASZ: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
AATP: Nephelometry
A1APR: Isoelectric Focusing
For billing questions, see Contacts
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
82103
1
82542
1
82104
1
If needed
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For most current information refer to the Marshfield Laboratory online reference manual.