Apolipoprotein B, Serum (APOLB)

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Marshfield Clinic Public WebSite

Test Code: APLBSO

Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding

Synonyms/Keywords

Apo B, APO-B, APOB, APOB-100, Apolipoprotein B-100

Useful For

Assessment of cardiovascular risk

Follow-up studies in individuals with non-HDL-C (or LDL-C) values inconsistent with risk factors or clinical presentation

Definitive studies of cardiac risk factors in individuals with significant family histories of coronary artery disease or other increased risk factors

Confirmation of suspected abetalipoproteinemia or hypobetalipoproteinemia

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Serum Separator Tube (SST)	Red Top Tube (RTT)	1 mL	0.5 mL

Collection Processing Instructions

Centrifuge and aliquot 1 ml of serum.

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Refrigerated (preferred)	8 days
	Frozen	60 days
	Ambient	24 hours

Rejection Criteria

Gross Hemolysis
Gross Icterus

Interference

In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Analytical Time	Methodology/Instrumentation
Mayo Clinic Laboratories	Monday through Saturday	1 day	Automated Turbidimetric Immunoassay

Reference Lab

Mayo Clinic Laboratories

Reference Range Information

Performing Location	Reference Range
Mayo Clinic Laboratories	<24 months: not established 2-17 years: Acceptable: <90 mg/dl Borderline high: 90-109 mg/dl High: >=110 mg/dl >18 years: Desirable: <90 mg/dl Above Desirable: 90-99 mg/dl Borderline high: 100-119 mg/dl High: 120-139 mg/dl Very high: >=140 mg/dl

Performing Location

Reference Range

Mayo Clinic Laboratories

<24 months: not established

2-17 years:

Acceptable: <90 mg/dl

Borderline high: 90-109 mg/dl

High: >=110 mg/dl

>18 years:

Desirable: <90 mg/dl

Above Desirable: 90-99 mg/dl

Borderline high: 100-119 mg/dl

High: 120-139 mg/dl

Very high: >=140 mg/dl

Interpretation

Elevated ApoB confers increased risk of atherosclerotic cardiovascular disease, even in a context of acceptable LDL cholesterol.

Extremely low values of ApoB (<48 mg/dl) are related to malabsorption of food lipids and can lead to polyneuropathy.

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
82172		1

Synonyms/Keywords

Apo B, APO-B, APOB, APOB-100, Apolipoprotein B-100

Ordering Applications

Ordering Application	Description
Cerner	Apolipoprotein B, S (APOLB)
COM	Apolipoprotein B, S (APOLB)

If the ordering application you are looking for is not listed, contact your local laboratory for assistance.

Specimen Requirements

Fasting Required	Specimen Type	Preferred Container/Tube	Acceptable Container/Tube	Specimen Volume	Specimen Minimum Volume (allows for 1 repeat)	Pediatric Minimum Volume (no repeat)
No	Serum	Serum Separator Tube (SST)	Red Top Tube (RTT)	1 mL	0.5 mL

Collection Processing

Centrifuge and aliquot 1 ml of serum.

Specimen Stability Information

Specimen Type	Temperature	Time
Serum	Refrigerated (preferred)	8 days
	Frozen	60 days
	Ambient	24 hours

Rejection Criteria

Gross Hemolysis
Gross Icterus

Interference

In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.

Useful For

Assessment of cardiovascular risk

Follow-up studies in individuals with non-HDL-C (or LDL-C) values inconsistent with risk factors or clinical presentation

Definitive studies of cardiac risk factors in individuals with significant family histories of coronary artery disease or other increased risk factors

Confirmation of suspected abetalipoproteinemia or hypobetalipoproteinemia

Reference Range Information

Performing Location	Reference Range
Mayo Clinic Laboratories	<24 months: not established 2-17 years: Acceptable: <90 mg/dl Borderline high: 90-109 mg/dl High: >=110 mg/dl >18 years: Desirable: <90 mg/dl Above Desirable: 90-99 mg/dl Borderline high: 100-119 mg/dl High: 120-139 mg/dl Very high: >=140 mg/dl

Performing Location

Reference Range

Mayo Clinic Laboratories

<24 months: not established

2-17 years:

Acceptable: <90 mg/dl

Borderline high: 90-109 mg/dl

High: >=110 mg/dl

>18 years:

Desirable: <90 mg/dl

Above Desirable: 90-99 mg/dl

Borderline high: 100-119 mg/dl

High: 120-139 mg/dl

Very high: >=140 mg/dl

Interpretation

Elevated ApoB confers increased risk of atherosclerotic cardiovascular disease, even in a context of acceptable LDL cholesterol.

Extremely low values of ApoB (<48 mg/dl) are related to malabsorption of food lipids and can lead to polyneuropathy.

For more information visit:

http://labtestsonline.org

Performing Laboratory Information

Performing Location	Day(s) Test Performed	Analytical Time	Methodology/Instrumentation
Mayo Clinic Laboratories	Monday through Saturday	1 day	Automated Turbidimetric Immunoassay

Reference Lab

Mayo Clinic Laboratories

For billing questions, see Contacts

Outreach CPTs

CPT	Modifier (if needed)	Quantity	Description	Comments
82172		1

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For most current information refer to the Marshfield Laboratory online reference manual.

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26159 Apolipoprotein B, Serum (APOLB)