26160 Anti-DNase B Titer, Serum (ADNAS)

​​ADB (Antideoxyribonuclease B), Anti-Dnase B, Antideoxyribonuclease, Antideoxyribonuclease B (ADB), DNA Streptococcal Antibody, DNase-B, Anti Streptococcal Antibodies, Serum ADNB

Demonstration of acute or recent streptococcal infection using anti-DNase B titer.

​This test was previously performed in-house, as test code “ADNB”. This test was discontinued and removed from the Marshfield test list in October, 2019, and is now only available to order as a single test, “ADNASSO”.
This test was also part of the in-house panel “ASA”. If this combination of testing is still desired, please order this test code along with test code “ASO”.

​Elevated values are consistent with an antecedent infection by group A streptococci. Although the antistreptolysin O (ASO) test is quite reliable, performing the anti-DNase is justified for 2 primary reasons. First, the ASO response is not universal. Elevated ASO titers are found in the sera of about 85% of individuals with rheumatic fever; ASO titers remain normal in about 15% of individuals with the disease. The same holds true for other streptococcal antibody tests: a significant portion of individuals with normal antibody titers for 1 test will have elevated antibody titers for another test. Thus, the percentage of false­ negatives can be reduced by performing 2 or more antibody tests. Second, skin infections, in contrast to throat infections, are associated with a poor ASO response. Patients with acute glomerulonephritis following skin infection (post-impetigo) have an attenuated immune response to streptolysin 0. For such patients, performance of an alternative streptococcal antibody test, such as this assay, is recommended.