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22165 Activated Protein C Resistance, Plasma

Activated Protein C Resistance, Plasma
Test Code: APCR
Synonyms/Keywords
​APC Resistance Ratio, Protein C Resistance
Useful For
This test is used to screen for the presence of factor V Leiden. Testing for this defect is indicated in evaluating patients with a history of venous thromboembolic disease.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ 0.75 mL ​ 0.75 mL​ 0.5 mL​
Collection Processing Instructions

​Patient must not be receiving low molecular weight or unfractionated heparin - recommend performing Factor V Leiden Mutation (FVL) in those cases.

One 0.75 mL citrated (BTT) plasma aliquot.

If more than one coagulation test is ordered, a separate aliquot is needed for each test.

- Collect in Citrated Blue Top Tube (BTT)
- Citrate anticoagulant must be adjusted for HCT >55%.
- Tube must be at least 90% full.
- Invert completely 3-4 times (without shaking) to mix.

*See Instructions for:  (Preparation of Platelet Poor Plasma)

Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Wednesday ​Less Than 2 Hours Optical clot detection /Siemens BCSXP​
Reference Range Information
Performing Location Reference Range
​Marshfield Normal range: 2.2 - 4.0  ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​85307 ​ ​ Optical clot detection​ ​
Synonyms/Keywords
​APC Resistance Ratio, Protein C Resistance
Ordering Applications
Ordering Application Description
​Centricity ​APC Resistance Ratio
​Cerner ​APC Resistance Ratio
​COM ​APC Resistance Ratio
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ 0.75 mL ​ 0.75 mL​ 0.5 mL​
Collection Processing

​Patient must not be receiving low molecular weight or unfractionated heparin - recommend performing Factor V Leiden Mutation (FVL) in those cases.

One 0.75 mL citrated (BTT) plasma aliquot.

If more than one coagulation test is ordered, a separate aliquot is needed for each test.

- Collect in Citrated Blue Top Tube (BTT)
- Citrate anticoagulant must be adjusted for HCT >55%.
- Tube must be at least 90% full.
- Invert completely 3-4 times (without shaking) to mix.

*See Instructions for:  (Preparation of Platelet Poor Plasma)

Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Useful For
This test is used to screen for the presence of factor V Leiden. Testing for this defect is indicated in evaluating patients with a history of venous thromboembolic disease.
Reference Range Information
Performing Location Reference Range
​Marshfield Normal range: 2.2 - 4.0  ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Wednesday ​Less Than 2 Hours Optical clot detection /Siemens BCSXP​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​85307 ​ ​ Optical clot detection​ ​
For most current information refer to the Marshfield Laboratory online reference manual.