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22178 Aldosterone, Urine (ALDU)

Aldosterone, Urine (ALDU)
Test Code: ALDOUSO
Synonyms/Keywords
​Ref Lab Code: 8556, Aldosterone w/Sodium, U
Aldosterone with Sodium, Urine
Useful For
​Investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter's syndrome)
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Urine​ Plastic, 10-mL urine tube​ ​ 10 mL​ 6mL​ ​
Collection Processing Instructions
​1. Collect urine for 24 hours.
2. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old. This preservative is intended to achieve a pH of between approximately 2 and 4. 
 
Indicate total 24 hour urine volume on request form. The total volume collected must be measured, recorded, and included with the test request
 
Additional Information:
1. 24-Hour volume is required.
2. See Urine Preservatives for multiple collections and Renin-Aldosterone Studies for more detailed instructions in Special Instructions.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ ​ Refrigerated (preferred)​ 7 days​
Ambient ​ 7 days​
Frozen ​ 7 days​
Rejection Criteria
​Acetic acid at less than 50% concentration as a preservative.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Monday, Thursday​ 2 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
0-30 days: 0.7-11.0 mcg/24 hr
31 days-11 months: 0.7-22.0 mcg/24 hr
>= 1 year: 2.0-20.0 mcg/24 hr
Interpretation
​Under normal circumstances, if the 24-hour urinary sodium excretion is >200 mEq, the urinary aldosterone excretion should be <10 mcg/24 hours.
 
Urinary aldosterone excretion >12 mcg/24 hours as part of an aldosterone suppression test is consistent with hyperaldosteronism.
 
24-Hour urinary sodium excretion should exceed 200 mEq to document adequate sodium repletion.
 
See Renin-Aldosterone Studies in Special Instructions.
 
Note: Advice on stimulation or suppression tests is available from Mayo Clinic's Division of Endocrinology and may be obtained by calling Mayo Medical Laboratories.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82088 ​ ​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 8556, Aldosterone w/Sodium, U
Aldosterone with Sodium, Urine
Ordering Applications
Ordering Application Description
Centricity​ ​Aldosterone-24Hr
​Cerner ​Aldosterone 24 Hour Urine (8556)
​COM ​Aldosterone - Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Urine​ Plastic, 10-mL urine tube​ ​ 10 mL​ 6mL​ ​
Collection Processing
​1. Collect urine for 24 hours.
2. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old. This preservative is intended to achieve a pH of between approximately 2 and 4. 
 
Indicate total 24 hour urine volume on request form. The total volume collected must be measured, recorded, and included with the test request
 
Additional Information:
1. 24-Hour volume is required.
2. See Urine Preservatives for multiple collections and Renin-Aldosterone Studies for more detailed instructions in Special Instructions.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ ​ Refrigerated (preferred)​ 7 days​
Ambient ​ 7 days​
Frozen ​ 7 days​
Rejection Criteria
​Acetic acid at less than 50% concentration as a preservative.
Useful For
​Investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter's syndrome)
Reference Range Information
0-30 days: 0.7-11.0 mcg/24 hr
31 days-11 months: 0.7-22.0 mcg/24 hr
>= 1 year: 2.0-20.0 mcg/24 hr
Interpretation
​Under normal circumstances, if the 24-hour urinary sodium excretion is >200 mEq, the urinary aldosterone excretion should be <10 mcg/24 hours.
 
Urinary aldosterone excretion >12 mcg/24 hours as part of an aldosterone suppression test is consistent with hyperaldosteronism.
 
24-Hour urinary sodium excretion should exceed 200 mEq to document adequate sodium repletion.
 
See Renin-Aldosterone Studies in Special Instructions.
 
Note: Advice on stimulation or suppression tests is available from Mayo Clinic's Division of Endocrinology and may be obtained by calling Mayo Medical Laboratories.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Monday, Thursday​ 2 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82088 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.