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22301 Antibody Titer

Antibody Titer
Test Code: ABSC
Synonyms/Keywords
​Indirect Coombs Antibody Titer, Prenatal Titer, Antibody Titration, Titration studies
Test Components
Titer, ABSC, Antibody Identification, Antigen Typing
Useful For
Antibody Titer can assist in the diagnosis and management of HDFN (Hemolytic Disease of the Fetus and Newborn).  When a prenatal patient has a positive antibody screen and the antibody specificity is either anti-D or other clinically significant IgG antibodies known to cause HDFN, titration studies are performed to determine the relative amount of the antibody. A clinically significant titer is generally considered to be 16 or higher, depending on the antibody specificity and institution.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ ​ Whole blood​ ​
Two 6 mL EDTA
Pink Top Tubes
(PTT)​ ​
Four 3 mL EDTA Lavender Top Tubes (LTT)
 OR
Two 6 mL Red Top Tubes (RTT)​
 Two 6 mL 6.0 mL ​ ​
Collection Processing Instructions
​Indicate in Comment of test “Antibody Titer” and specificity of antibody, if known (e.g. “Antibody Titer; Anti-c”).
Specimen Stability Information
Specimen Type Temperature Time
Whole blood/serum​ Refrigerate​ <14 days old​
Rejection Criteria
Serum separator tubes (SST)
Frozen-if ABSC ordered​
Hemolyzed​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Sunday​ 2-4 hours​ Serological​
Test Information
​An antibody screen may be performed to determine the presence of atypical antibodies. If positive, antibody identification and antigen typing will be performed as part of confirmatory testing.
Reference Range Information
Performing Location Reference Range
​Marshfield No reference ranges are available.  ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86886 ​ ​
​Titer
 ​
​86850 ​ ​ ​ABSC ​
​86905 ​ ​ ​AGPAT ​
​86077 ​ ​ CONSULT ​
Synonyms/Keywords
​Indirect Coombs Antibody Titer, Prenatal Titer, Antibody Titration, Titration studies
Test Components
Titer, ABSC, Antibody Identification, Antigen Typing
Ordering Applications
Ordering Application Description
​ ​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ ​ Whole blood​ ​
Two 6 mL EDTA
Pink Top Tubes
(PTT)​ ​
Four 3 mL EDTA Lavender Top Tubes (LTT)
 OR
Two 6 mL Red Top Tubes (RTT)​
 Two 6 mL 6.0 mL ​ ​
Collection Processing
​Indicate in Comment of test “Antibody Titer” and specificity of antibody, if known (e.g. “Antibody Titer; Anti-c”).
Specimen Stability Information
Specimen Type Temperature Time
Whole blood/serum​ Refrigerate​ <14 days old​
Rejection Criteria
Serum separator tubes (SST)
Frozen-if ABSC ordered​
Hemolyzed​
Useful For
Antibody Titer can assist in the diagnosis and management of HDFN (Hemolytic Disease of the Fetus and Newborn).  When a prenatal patient has a positive antibody screen and the antibody specificity is either anti-D or other clinically significant IgG antibodies known to cause HDFN, titration studies are performed to determine the relative amount of the antibody. A clinically significant titer is generally considered to be 16 or higher, depending on the antibody specificity and institution.
Test Components
Titer, ABSC, Antibody Identification, Antigen Typing
Reference Range Information
Performing Location Reference Range
​Marshfield No reference ranges are available.  ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Sunday​ 2-4 hours​ Serological​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86886 ​ ​
​Titer
 ​
​86850 ​ ​ ​ABSC ​
​86905 ​ ​ ​AGPAT ​
​86077 ​ ​ CONSULT ​
For most current information refer to the Marshfield Laboratory online reference manual.