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22322 Antiphospholipid Antibody Syndrome Panel

Antiphospholipid Antibody Syndrome Panel
Test Code: APS
Synonyms/Keywords
​APA Syndrome Panel, ACLSCN, DRVVT, PTTLA
Test Components
​Cardiolipin Ab Screen (ACLSCN), Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA). 
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum
and *Platelet Poor Plasma
 Red Top Tube (RTT) and 3.2% Citrated Blue Top Tube (BTT)​ Serum Separator Tube (STT)​ 2.0 mL serum and two 0.75 mL  citrated plasma​ 2.0 mL serum and one 0.75 mL citrated plasma​ 0.2 mL serum and one 0.5 mL citrated plasma​
Collection Processing Instructions
​Serum (RTT or SST): Samples collected in a RTT must be removed from the clot within one hour for storage or transport. Samples collected in a SST must be processed and serum removed from the primary tube within 4 hours for storage or transport.

Citrated Plasma (BTT): 
- Collect in Citrated Blue Top Tube (BTT)
- Citrate anticoagulant must be adjusted for HCT >55%.
- Tube must be at least 90% full.
- Invert completely 3-4 times (without shaking) to mix.
*See Instructions for: Preparation of Platelet Poor Plasma
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Refrigerate ​2 days
​Frozen ​6 months
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
Specimens that thaw during storage or transport​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ ACLSCN: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
​ DRVVT: Monday, Wednesday, Friday​ Less than 2 hours​ Optical Clot Detection/Siemens BCSXP​
​ PTT-LA: Monday, Wednesday, Friday​ Less than 2 hours​ Optical Clot Detection/Siemens BCSXP​
​ ACLA: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
​ ACLG: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
​ ACLM: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
Test Information
​Patients on Coumadin may be tested.  An Anticardiolipin Ab Screen (ACLSCN), dilute Russells Viper Venom Time (DRVVT) and a PTT-Lupus Anticoagulant (PTTLA) will be performed.  If the ACLSCN is positive an Anticardiolipin IgA (ACLA), Anticardiolipin IgG (ACLG) and an Anticardiolipin IgM (ACLM) will be performed.
 
Requested panel includes Lupus anticoagulant testing (DRVVT and PTT-LA), these tests should not be performed on patients receiving rivaroxaban, apixaban, dabigatran, edoxaban, or warfarin.  For patients on these medications, order the anticardiolipin antibody and/or anti-beta-2 glycoprotein 1 antibody tests individually instead of the panel.
Reference Range Information
Performing Location Reference Range
​Marshfield See individual test listings for reference ranges.​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86147​ ​ ​ Cardiolipin Ab Screen​ ​
85613​ ​ ​ Russell Viper Venom Time, diluted ​ ​
85732​ ​ ​ PTTLA​ ​
86147​ ​ 3​ ACL IgA, IgG, IgM If needed
Synonyms/Keywords
​APA Syndrome Panel, ACLSCN, DRVVT, PTTLA
Test Components
​Cardiolipin Ab Screen (ACLSCN), Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA). 
Ordering Applications
Ordering Application Description
​Centricity ​Anti-phos Ab Syndrome
​Cerner ​Antiphospholipid Ab Syndrome
​COM ​Antiphospholipid Ab Syndrome
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum
and *Platelet Poor Plasma
 Red Top Tube (RTT) and 3.2% Citrated Blue Top Tube (BTT)​ Serum Separator Tube (STT)​ 2.0 mL serum and two 0.75 mL  citrated plasma​ 2.0 mL serum and one 0.75 mL citrated plasma​ 0.2 mL serum and one 0.5 mL citrated plasma​
Collection Processing
​Serum (RTT or SST): Samples collected in a RTT must be removed from the clot within one hour for storage or transport. Samples collected in a SST must be processed and serum removed from the primary tube within 4 hours for storage or transport.

Citrated Plasma (BTT): 
- Collect in Citrated Blue Top Tube (BTT)
- Citrate anticoagulant must be adjusted for HCT >55%.
- Tube must be at least 90% full.
- Invert completely 3-4 times (without shaking) to mix.
*See Instructions for: Preparation of Platelet Poor Plasma
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​Refrigerate ​2 days
​Frozen ​6 months
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
Specimens that thaw during storage or transport​
Test Components
​Cardiolipin Ab Screen (ACLSCN), Dilute Russell Viper Venom Time (DRVVT), PTT-Lupus Anticoagulant (PTT-LA). 
Reference Range Information
Performing Location Reference Range
​Marshfield See individual test listings for reference ranges.​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ ACLSCN: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
​ DRVVT: Monday, Wednesday, Friday​ Less than 2 hours​ Optical Clot Detection/Siemens BCSXP​
​ PTT-LA: Monday, Wednesday, Friday​ Less than 2 hours​ Optical Clot Detection/Siemens BCSXP​
​ ACLA: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
​ ACLG: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
​ ACLM: Monday, Wednesday, Friday​ 2-4 hours​ ELISA​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86147​ ​ ​ Cardiolipin Ab Screen​ ​
85613​ ​ ​ Russell Viper Venom Time, diluted ​ ​
85732​ ​ ​ PTTLA​ ​
86147​ ​ 3​ ACL IgA, IgG, IgM If needed
For most current information refer to the Marshfield Laboratory online reference manual.