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22454 Factor 5 (V) Leiden

Factor 5 (V) Leiden
Test Code: FVL
Synonyms/Keywords
​Factor V Leiden Mutation Test, FV R506Q
Useful For
​People with Factor V Leiden (G1691A) or prothrombin G20210A mutations have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT).  Factor V Leiden mutation and Prothrombin G20210A tests are ordered when it is suspected that a person has an inherited risk factor for thrombosis, for example, in someone who has a first DVT or venous thromboembolism (VTE) before age 50 or in an unusual part of the body.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Whole Blood EDTA Lavender Top Tube (LTT) ​Citrated Blue Top Tube (BTT) 1.0 mL​ 1.0 mL​ 0.5 mL​
Collection Processing Instructions
​Tube must be drawn at least 90% full. Invert tube completely three or four times to mix. Do not shake. Do not open tube. Note: The blood specimen tube must not be opened prior to analysis. Uncentrifuged specimens preferred.
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​Refrigerate <= 7 days
Rejection Criteria
Clotted
​>7 days old
​Tubes that have been opened
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday *6 hours​ ​PCR/Hybridization Probe
Reference Range Information
Performing Location Reference Range
​Marshfield ​Heterozygous,  Homozygous, or  Normal (No evidence of FV Leiden).
Interpretation

​Heterozygous for Factor V Leiden: the relative risk of venous thrombosis is about 7-fold that of the general population. Other conditions, either acquired or inherited, may act synergistically to increase an individual's thrombotic risk.

Homozygous for Factor V Leiden: the relative risk of venous thrombosis is about 70-fold that of the general population. Other conditions, either acquired or inherited, may act synergistically to increase an individual's thrombotic risk.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81241 ​ ​ ​ ​
Synonyms/Keywords
​Factor V Leiden Mutation Test, FV R506Q
Ordering Applications
Ordering Application Description
​Centricity

Factor 5 (V) Leiden Profile

or

​Factor-V Leiden

​Cerner ​Factor V Leiden
​COM ​Factor 5 (V) Leiden
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Whole Blood EDTA Lavender Top Tube (LTT) ​Citrated Blue Top Tube (BTT) 1.0 mL​ 1.0 mL​ 0.5 mL​
Collection Processing
​Tube must be drawn at least 90% full. Invert tube completely three or four times to mix. Do not shake. Do not open tube. Note: The blood specimen tube must not be opened prior to analysis. Uncentrifuged specimens preferred.
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​Refrigerate <= 7 days
Rejection Criteria
Clotted
​>7 days old
​Tubes that have been opened
Useful For
​People with Factor V Leiden (G1691A) or prothrombin G20210A mutations have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT).  Factor V Leiden mutation and Prothrombin G20210A tests are ordered when it is suspected that a person has an inherited risk factor for thrombosis, for example, in someone who has a first DVT or venous thromboembolism (VTE) before age 50 or in an unusual part of the body.
Reference Range Information
Performing Location Reference Range
​Marshfield ​Heterozygous,  Homozygous, or  Normal (No evidence of FV Leiden).
Interpretation

​Heterozygous for Factor V Leiden: the relative risk of venous thrombosis is about 7-fold that of the general population. Other conditions, either acquired or inherited, may act synergistically to increase an individual's thrombotic risk.

Homozygous for Factor V Leiden: the relative risk of venous thrombosis is about 70-fold that of the general population. Other conditions, either acquired or inherited, may act synergistically to increase an individual's thrombotic risk.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday *6 hours​ ​PCR/Hybridization Probe
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81241 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.