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22565 Digoxin

Digoxin
Test Code: DIGOX
Synonyms/Keywords
Lanoxin, DIG, Digitalis​
Useful For
Digoxin, which improves the pumping action of the heart, is an inotropic agent. It is the cardiac glycoside most frequently prescribed for the treatment of congestive heart failure and disorders characterized by abnormal heart rate.  Digoxin functions by stimulating the contraction of heart muscle and slowing ventricular rate.  Toxicity is frequently of concern.  ​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Plasma​/Serum Lithium-heparin Plasma Separator (PST), Serum Separator Tube (SST) ​Lithium or Sodium-heparin Green Top (GTT)​, Red Top Tube (RTT) 1 mL​ 0.3 mL​ 0.6 mL whole blood​
Collection Processing Instructions
Collect specimen no sooner than 8 hours after last dose.
Remove sample from cells as soon as possible after collection.
Plasma/serum must be removed from gel within 24 hours of collection. ​
Specimen Stability Information
Specimen Type Temperature Time
Plasma​/Serum ​ Refrigerate​ 7 days​
Frozen​ 1 year​
Rejection Criteria
Plasma/serum not removed from gel within 24 hours of collection.
Interference
​For testing performed at The Diagnostic & Treatment Center lab (Weston Center): High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Diagnostic Treatment Center​ ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
Eau Claire​ ​Monday through Sunday ​Less than 2 hours ​Immunoassay Technique/Siemens Dimension
​Flambeau Hospital ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
​Ladysmith Medical Center ​Monday through Sunday ​Less than 2 hours ​Immunoassay Technique/Siemens Dimension
​Lakeview Medical Center ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
Marshfield​ Monday through Sunday​ Less than 2 hours​ Emit*2000 Rate Assay/Beckman AU
​Minocqua ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
Neillsville​​Monday through Sunday​​Less than 2 hours​​​Immunoassay Technique/Siemens Dimension
​Wausau ​Monday through Sunday ​Less than 2 hours ​Immunoassay Technique/Siemens Dimension
Test Information
Monitor serum level 8-24 hours after dosing (either oral or IV), or before administration of next dose. At this interval, equilibration with tissues is optimal and levels will correlate best with cardiac activity. With normal renal function, time to a new steady state level is 5 days - 2 weeks (or longer with reduced renal function or congestive heart failure).
Half life (healthy adult): 30 - 35 hours.
Time to peak level: Plasma = 2 - 3 hours after last dose; Tissues = at least 8 hours after last dose. Quinidine, verapamil, amiodarone or flecainide decrease clearance of digoxin and increase plasma levels.​
Reference Range Information
Performing Location Reference Range
All Performing Sites Therapeutic: 0.5-2.0 ng/mL​
​See Critical Value List for list of current critical values ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80162 ​ ​ ​ ​ ​
Synonyms/Keywords
Lanoxin, DIG, Digitalis​
Ordering Applications
Ordering Application Description
​Centricity

​a. Digoxin (Lanoxin)

b. Lanoxin (Digoxin)

c. Digoxin

​Cerner ​Digoxin Level
​COM ​Digoxin
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Plasma​/Serum Lithium-heparin Plasma Separator (PST), Serum Separator Tube (SST) ​Lithium or Sodium-heparin Green Top (GTT)​, Red Top Tube (RTT) 1 mL​ 0.3 mL​ 0.6 mL whole blood​
Collection Processing
Collect specimen no sooner than 8 hours after last dose.
Remove sample from cells as soon as possible after collection.
Plasma/serum must be removed from gel within 24 hours of collection. ​
Specimen Stability Information
Specimen Type Temperature Time
Plasma​/Serum ​ Refrigerate​ 7 days​
Frozen​ 1 year​
Rejection Criteria
Plasma/serum not removed from gel within 24 hours of collection.
Interference
​For testing performed at The Diagnostic & Treatment Center lab (Weston Center): High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Useful For
Digoxin, which improves the pumping action of the heart, is an inotropic agent. It is the cardiac glycoside most frequently prescribed for the treatment of congestive heart failure and disorders characterized by abnormal heart rate.  Digoxin functions by stimulating the contraction of heart muscle and slowing ventricular rate.  Toxicity is frequently of concern.  ​
Reference Range Information
Performing Location Reference Range
All Performing Sites Therapeutic: 0.5-2.0 ng/mL​
​See Critical Value List for list of current critical values ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Diagnostic Treatment Center​ ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
Eau Claire​ ​Monday through Sunday ​Less than 2 hours ​Immunoassay Technique/Siemens Dimension
​Flambeau Hospital ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
​Ladysmith Medical Center ​Monday through Sunday ​Less than 2 hours ​Immunoassay Technique/Siemens Dimension
​Lakeview Medical Center ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
Marshfield​ Monday through Sunday​ Less than 2 hours​ Emit*2000 Rate Assay/Beckman AU
​Minocqua ​Monday through Sunday​ ​Less than 2 hours​ ​Immunoassay Technique/Siemens Dimension
Neillsville​​Monday through Sunday​​Less than 2 hours​​​Immunoassay Technique/Siemens Dimension
​Wausau ​Monday through Sunday ​Less than 2 hours ​Immunoassay Technique/Siemens Dimension
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80162 ​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.