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22603 IgA Subclasses (IGAS)

IgA Subclasses (IGAS)
Test Code: MISC
Synonyms/Keywords
​Ref Lab Code: 87938, IgA Subclasses, S
Useful For
​Investigation of immune deficiency due to IgA2 deficiency
 
Evaluating patients with anaphylactic transfusion reactions
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Collection Processing Instructions
​Patient age required for specific reference ranges.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerated (preferred)​ 7 days​
​ Ambient ​ 7 days​
​ Frozen ​ 7 days​
Rejection Criteria
Gross lipemia
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Monday through Saturday​ 1 day​
Nephelometry for Total IgA, IgA1, and IgA2​
Reference Lab
Mayo Clinic Laboratories
Test Information
​Test includes IgA, IgA1, and IgA2.
Reference Range Information
Interpretive report
Interpretation
​Low concentrations of IgA2 with normal IgA1 levels suggest an IgA2 deficiency.
 
Elevated concentrations of IgA2 with normal or low amounts of IgA1 suggest a clonal plasma cell proliferative disorder secreting a monoclonal IgA2.
 
Increased total IgA levels also may be seen in benign disorders (eg, infection, inflammation, allergy), hyper IgD syndrome with periodic fever and monoclonal gammopathies (eg, myeloma, monoclonal gammopathies of undetermined significance [MGUS]).
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83883 ​ 3​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 87938, IgA Subclasses, S
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Collection Processing
​Patient age required for specific reference ranges.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerated (preferred)​ 7 days​
​ Ambient ​ 7 days​
​ Frozen ​ 7 days​
Rejection Criteria
Gross lipemia
Useful For
​Investigation of immune deficiency due to IgA2 deficiency
 
Evaluating patients with anaphylactic transfusion reactions
Reference Range Information
Interpretive report
Interpretation
​Low concentrations of IgA2 with normal IgA1 levels suggest an IgA2 deficiency.
 
Elevated concentrations of IgA2 with normal or low amounts of IgA1 suggest a clonal plasma cell proliferative disorder secreting a monoclonal IgA2.
 
Increased total IgA levels also may be seen in benign disorders (eg, infection, inflammation, allergy), hyper IgD syndrome with periodic fever and monoclonal gammopathies (eg, myeloma, monoclonal gammopathies of undetermined significance [MGUS]).
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Monday through Saturday​ 1 day​
Nephelometry for Total IgA, IgA1, and IgA2​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83883 ​ 3​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.