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22605 IgG Subclasses (IGGS)

IgG Subclasses (IGGS)
Test Code: IGGMAYO
Synonyms/Keywords
​Ref Lab Code: 9259, IgG (Immunoglobulin G) Subclasses, IgG Subclasses, IgG1, IgG1, IgG2, IgG3, IgG4 (Immunoglobulins G1, G2, G3, G4), IgG2,I gG3, IgG4, Immunoglobulin G (IgG),Subclasses, IgG (Immunoglobulin G)
Useful For
​A second-order test for evaluating patients with clinical signs and symptoms of humoral immunodeficiency or combined immunodeficiency (cellular and humoral)
 
Testing for immunoglobulin G (IgG) subclass levels may be indicated in hypogammaglobulinemic patients, and in patients with clinical evidence of a possible immunodeficiency with a normal level of total IgG protein in serum
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerated (preferred)​ 14 days​
​ Ambient ​ 14 days​
​ Frozen ​ 14 days​
Rejection Criteria
Gross lipemia
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Monday through Saturday​ 1 day​
Nephelometry
Includes total immunoglobulin G.​
Reference Lab
Mayo Clinic Laboratories
Test Information
​Test can also be performed by Brigham and Womens Hospital if specifically requested by physician--see separate listing. Useful for investigating recurrent respiratory infections, recurrent otitis media, and impaired lung function with or without IgA deficiency.
Reference Range Information
Interpretive report
Interpretation
​Diminished concentrations of all immunoglobulin G (IgG) subclasses are found in common variable immunodeficiency, combined immunodeficiency, ataxia telangiectasia, and other primary and acquired immunodeficiency diseases.  
 
A diminished concentration of IgG2 protein may be clinically significant in the context of recurrent sinopulmonary infection and may occur with or without concomitant immunoglobulin A deficiency.
 
Slightly diminished concentrations of 1 or more IgG subclass proteins are not uncommon, and usually have little clinical significance.
 
Conversely, some individuals with deficient specific antibody responses to polysaccharide antigens may have normal serum levels of IgG subclasses.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82787​ ​ 4​ IgG subclasses​ ​
​82784 ​ ​ IgG​ ​
Synonyms/Keywords
​Ref Lab Code: 9259, IgG (Immunoglobulin G) Subclasses, IgG Subclasses, IgG1, IgG1, IgG2, IgG3, IgG4 (Immunoglobulins G1, G2, G3, G4), IgG2,I gG3, IgG4, Immunoglobulin G (IgG),Subclasses, IgG (Immunoglobulin G)
Ordering Applications
Ordering Application Description
​Centricity ​IgG Subclasses-Mayo
​Cerner ​IgG Subclasses (9259)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 1 mL​ 0.5 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerated (preferred)​ 14 days​
​ Ambient ​ 14 days​
​ Frozen ​ 14 days​
Rejection Criteria
Gross lipemia
Useful For
​A second-order test for evaluating patients with clinical signs and symptoms of humoral immunodeficiency or combined immunodeficiency (cellular and humoral)
 
Testing for immunoglobulin G (IgG) subclass levels may be indicated in hypogammaglobulinemic patients, and in patients with clinical evidence of a possible immunodeficiency with a normal level of total IgG protein in serum
Reference Range Information
Interpretive report
Interpretation
​Diminished concentrations of all immunoglobulin G (IgG) subclasses are found in common variable immunodeficiency, combined immunodeficiency, ataxia telangiectasia, and other primary and acquired immunodeficiency diseases.  
 
A diminished concentration of IgG2 protein may be clinically significant in the context of recurrent sinopulmonary infection and may occur with or without concomitant immunoglobulin A deficiency.
 
Slightly diminished concentrations of 1 or more IgG subclass proteins are not uncommon, and usually have little clinical significance.
 
Conversely, some individuals with deficient specific antibody responses to polysaccharide antigens may have normal serum levels of IgG subclasses.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​
 Monday through Saturday​ 1 day​
Nephelometry
Includes total immunoglobulin G.​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82787​ ​ 4​ IgG subclasses​ ​
​82784 ​ ​ IgG​ ​
For most current information refer to the Marshfield Laboratory online reference manual.