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22631 Filaria IgG4 Antibody, Serum (FFAG4)

Filaria IgG4 Antibody, Serum (FFAG4)
Test Code: MISC
Synonyms/Keywords
Filaria IgG4 Antibody
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 0.5 mL​ 0.1 mL​ ​
Collection Processing Instructions
​Spin down and send serum in a plastic vial.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ ​ ​14 days
Room Temperature 7 days​
Frozen ​ ​ ​30 days
Rejection Criteria
Gross hemolysis or lipemia
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories who forwards to Focus Diagnostics​
Wednesday
​
1-8 days
​
Enzyme-Linked Immunosorbent Assay (ELISA)​
Reference Lab
Mayo Clinic Laboratories
Test Information
​Sent to Mayo Medical Laboratories who forwards to Focus Diagnostics.
Reference Range Information
Reference Range: <1:50
Interpretation

Interpretive Criteria:

<1:50 Negative
1.50-3.00 Equivocal
>3.00 Positive

This assay detects Filaria IgG4 associated with infections caused by the major filarial parasites, including Dirofilaria immitis, Wuchereria brancrofti, Brugia malayi, and Onchocerca volvulus. Detection of IgG4 subclass antibody offers enhanced specificity without sacrifice of sensitivity. Chronic filarial infections manifesting as elephantiasis may not show a significant IgG4 response, and cannot be ruled out by this assay. Equivocal results may represent cross-reactive antibodies induced by infection with other nematodes.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86682 ​ ​ ​ ​
Synonyms/Keywords
Filaria IgG4 Antibody
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Red Top Tube (RTT)​ Serum Separator Tube (SST)​ 0.5 mL​ 0.1 mL​ ​
Collection Processing
​Spin down and send serum in a plastic vial.
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ ​ ​14 days
Room Temperature 7 days​
Frozen ​ ​ ​30 days
Rejection Criteria
Gross hemolysis or lipemia
Reference Range Information
Reference Range: <1:50
Interpretation

Interpretive Criteria:

<1:50 Negative
1.50-3.00 Equivocal
>3.00 Positive

This assay detects Filaria IgG4 associated with infections caused by the major filarial parasites, including Dirofilaria immitis, Wuchereria brancrofti, Brugia malayi, and Onchocerca volvulus. Detection of IgG4 subclass antibody offers enhanced specificity without sacrifice of sensitivity. Chronic filarial infections manifesting as elephantiasis may not show a significant IgG4 response, and cannot be ruled out by this assay. Equivocal results may represent cross-reactive antibodies induced by infection with other nematodes.

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Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories who forwards to Focus Diagnostics​
Wednesday
​
1-8 days
​
Enzyme-Linked Immunosorbent Assay (ELISA)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86682 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.