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22649 Fungal Antibody Panel, Systemic

Fungal Antibody Panel, Systemic
Test Code: FUNGAL
Synonyms/Keywords
Blastomyces, Histoplasma, Coccidioides, antibody, serology, fungal
Test Components
Includes Blastomyces, Coccidioides, Histoplasma yeast and mycelial antibodies.​
Useful For
Serological diagnosis of fungus infections due to Blastomyces dermatitidis, Histoplasma capsulatum, or Coccidioides immitis.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) ​ Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 3 days​
Freeze​ >3 days​
Rejection Criteria
Hemolyzed samples
​Lipemic samples
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Wednesdays​
​3 days -
results available Friday (pm)
Immunodiffusion (Double Immunodiffusion or Ouchterlony Method)
Test Information
Patient should be off steroids for 2-4 weeks or a false negative may occur.
 
Detectable antibody levels may not be present from patients with early, primary infections (first 3-6 weeks) or from immunocompromised or immunosuppressed patients.


This test uses radial immunodiffusion to identify antibodies to B. dermatitidis, H. capsulatum, or C. immitis in patient sera.

Reference Range Information
Performing Location Reference Range
Marshfield ​ Negative ​
Interpretation

The C. immitis component will now report antibody responses to two distinct antigens, IDTP and IDCF. These results may be interpreted as follows:

- IDTP+/IDCF- Consistent with an early acute case of C. immitis infection.
- IDTP+/IDCF+ Consistent with an acute or early convalescent case of C. immitis infection.
- IDTP-/IDCF+ Consistent with a resolved or chronic case of C. immitis infection.
- IDTP-/IDCF- No serological evidence of C. immitis infection.

While IDTP & IDCF reactions closely follow those of IgM and IgG respectively, they are not strict measurements of those immunoglobulin classes.

Detectable antibody levels may not be present in patients with early, primary infections (first 3-6 weeks) or in immunosuppressed patients. Antibodies to B. dermatitidis, H. capsulatum, or C. immitis can cross-react to cause false positive reactions to other fungi that are detected in this test. Results should thus be considered in their entirety together with other diagnostic and clinical information.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86635 ​ ​ 2 Coccidioides antibody​ ​
86612​ ​ ​1 Blastomyces antibody ​ ​
86698​ ​ ​1 Histoplasma antibody ​ ​
Synonyms/Keywords
Blastomyces, Histoplasma, Coccidioides, antibody, serology, fungal
Test Components
Includes Blastomyces, Coccidioides, Histoplasma yeast and mycelial antibodies.​
Ordering Applications
Ordering Application Description
​Centricity ​Fungal Ab Panel
​Cerner ​Fungal Ab Panel
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) ​ Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ Refrigerate​ 3 days​
Freeze​ >3 days​
Rejection Criteria
Hemolyzed samples
​Lipemic samples
Useful For
Serological diagnosis of fungus infections due to Blastomyces dermatitidis, Histoplasma capsulatum, or Coccidioides immitis.
Test Components
Includes Blastomyces, Coccidioides, Histoplasma yeast and mycelial antibodies.​
Reference Range Information
Performing Location Reference Range
Marshfield ​ Negative ​
Interpretation

The C. immitis component will now report antibody responses to two distinct antigens, IDTP and IDCF. These results may be interpreted as follows:

- IDTP+/IDCF- Consistent with an early acute case of C. immitis infection.
- IDTP+/IDCF+ Consistent with an acute or early convalescent case of C. immitis infection.
- IDTP-/IDCF+ Consistent with a resolved or chronic case of C. immitis infection.
- IDTP-/IDCF- No serological evidence of C. immitis infection.

While IDTP & IDCF reactions closely follow those of IgM and IgG respectively, they are not strict measurements of those immunoglobulin classes.

Detectable antibody levels may not be present in patients with early, primary infections (first 3-6 weeks) or in immunosuppressed patients. Antibodies to B. dermatitidis, H. capsulatum, or C. immitis can cross-react to cause false positive reactions to other fungi that are detected in this test. Results should thus be considered in their entirety together with other diagnostic and clinical information.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Wednesdays​
​3 days -
results available Friday (pm)
Immunodiffusion (Double Immunodiffusion or Ouchterlony Method)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86635 ​ ​ 2 Coccidioides antibody​ ​
86612​ ​ ​1 Blastomyces antibody ​ ​
86698​ ​ ​1 Histoplasma antibody ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.