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22808 Ketoconazole Level (51685)

Ketoconazole Level (51685)
Test Code: MISC
Synonyms/Keywords
​ Ketoconazole Assay
Useful For
​Ketoconazole is an antifungal that impairs fungal cell synthesis of ergosterol, an imperative component of the fungal cell membrane. Tablets of ketoconazole may be administered orally in treating systemic infections, for which serum levels may be monitored. Ketoconazole may also be administered as a topical cream for the treatment of dandruff and tinea versicolor, but this application does not generate detectable serum levels. Measurement of serum ketoconazole levels may be helpful to optimize drug dosing regimens, particularly where there is non-compliance, concern about drug interactions, pharmacokinetic variability, or suspected toxicity.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ 2.0 mL​ 0.5 mL​ ​
​CSF ​ ​ 1.0 mL​ ​0.5 mL ​
​Urine ​ ​ ​1.0 mL ​0.5 mL ​
​Body fluid ​ ​ 1.0 mL​ ​0.5 mL ​
Collection Processing Instructions
​Freeze in plastic tube and send on dry ice.
Specimen Stability Information
Specimen Type Temperature
​All sample types ​Frozen
Rejection Criteria
Serum separator tubes (SST)
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Focus Diagnostics​ ​ 4-5 days​ High Performance Liquid Chromatography​
Reference Lab
Focus Diagnostics
Test Information
​List all antimicrobials being used to treat patient.
Specimens collected just before or within 15 minutes of the next dose represent the TROUGH level. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level.
Reference Range Information

<0.1 mcg/mL

Therapeutic levels:
    Peak: 4.0 mcg/mL.
    Trough: Not well established.
Reference ranges for other specimens by interpretive report.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80299 ​ ​ ​ ​
Synonyms/Keywords
​ Ketoconazole Assay
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ 2.0 mL​ 0.5 mL​ ​
​CSF ​ ​ 1.0 mL​ ​0.5 mL ​
​Urine ​ ​ ​1.0 mL ​0.5 mL ​
​Body fluid ​ ​ 1.0 mL​ ​0.5 mL ​
Collection Processing
​Freeze in plastic tube and send on dry ice.
Specimen Stability Information
Specimen Type Temperature
​All sample types ​Frozen
Rejection Criteria
Serum separator tubes (SST)
Useful For
​Ketoconazole is an antifungal that impairs fungal cell synthesis of ergosterol, an imperative component of the fungal cell membrane. Tablets of ketoconazole may be administered orally in treating systemic infections, for which serum levels may be monitored. Ketoconazole may also be administered as a topical cream for the treatment of dandruff and tinea versicolor, but this application does not generate detectable serum levels. Measurement of serum ketoconazole levels may be helpful to optimize drug dosing regimens, particularly where there is non-compliance, concern about drug interactions, pharmacokinetic variability, or suspected toxicity.
Reference Range Information

<0.1 mcg/mL

Therapeutic levels:
    Peak: 4.0 mcg/mL.
    Trough: Not well established.
Reference ranges for other specimens by interpretive report.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Focus Diagnostics​ ​ 4-5 days​ High Performance Liquid Chromatography​
Reference Lab
Focus Diagnostics
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80299 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.