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22846 Pyruvate Kinase, Erythrocytes (PK)

Pyruvate Kinase, Erythrocytes (PK)
Test Code: MISC
Synonyms/Keywords
​Ref Lab Code: 8659, PK (Pyruvate Kinase), Pyruvate Kinase (RBC)
Useful For
Work-up of cases of nonspherocytic hemolytic anemia
 
Investigating families with pyruvate kinase deficiency to determine inheritance pattern and for genetic counseling​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole Blood​ ​Yellow top (ACD solution B) ​EDTA Lavender Top Tube ​6 mL ​1 mL ​
Collection Processing Instructions
​Do not transfer blood to other containers.
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​Refrigerated ​20 days
Rejection Criteria
Hemolysis Mild OK; Gross reject
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratory Monday through Saturday​ ​1 day
Kinetic Spectrophotometry (KS)​
Reference Lab
Mayo Clinic Laboratories
Test Information
Deficiencies of most of the enzymes of the Embden-Meyerhof (glycolytic) pathway, including pyruvate kinase (PK), have been reported. PK deficiency, although rare, is the erythrocyte enzyme deficiency most frequently found to be a cause of congenital nonspherocytic hemolytic anemia. It is an autosomal recessive disorder. Thus, the parents of affected patients are heterozygotes. Patients usually present during early childhood with anemia, icterus, and splenomegaly. Hemolytic disease of the newborn is common in persons with PK deficiency. ​
Reference Range Information
6.7-14.3 U/g hemoglobin
Interpretation
Most pyruvate kinase (PK) deficient patients have 5% to 25% of normal activity.
 
Elevated PK concentrations can be found in those patients with younger erythrocyte population. This may be due to the patient being a newborn or young red cells are being produced in response to the anemia (reticulocytosis).
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​84220 ​ ​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 8659, PK (Pyruvate Kinase), Pyruvate Kinase (RBC)
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole Blood​ ​Yellow top (ACD solution B) ​EDTA Lavender Top Tube ​6 mL ​1 mL ​
Collection Processing
​Do not transfer blood to other containers.
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​Refrigerated ​20 days
Rejection Criteria
Hemolysis Mild OK; Gross reject
Useful For
Work-up of cases of nonspherocytic hemolytic anemia
 
Investigating families with pyruvate kinase deficiency to determine inheritance pattern and for genetic counseling​
Reference Range Information
6.7-14.3 U/g hemoglobin
Interpretation
Most pyruvate kinase (PK) deficient patients have 5% to 25% of normal activity.
 
Elevated PK concentrations can be found in those patients with younger erythrocyte population. This may be due to the patient being a newborn or young red cells are being produced in response to the anemia (reticulocytosis).
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Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratory Monday through Saturday​ ​1 day
Kinetic Spectrophotometry (KS)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​84220 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.