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22873 Metanephrine Fractionation, Urine Random

Metanephrine Fractionation, Urine Random
Test Code: MET-RND
Synonyms/Keywords
Metanephrine, Normetanephrine; Metanephrines/Creatinine Ratio​
Test Components
Urine Metanephrine, Normetanephrine and Creatinine give a Metanephrine/Creatinine Ratio​
Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage cup with 0.1 g sulfamic acid
50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5​
 10 mL​ 5 mL urine​ 5 mL urine​
Collection Processing Instructions
Collection instruction: If random specimens are collected unpreserved, specimen must be hand carried to the lab for immediate addition of 0.1 grams of sulfamic acid. If preferred or acceptable container preservatives are unavailable, the unpreserved sample can be immediately frozen and transported frozen to Marshfield labs.
 
Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ (preserved) ​ Refrigerate​ 1 week
​Frozen​1 week
​Urine (unpreserved) ​​Refrigerate​48 hours
​Frozen​48 hours
Rejection Criteria
​Specimens that are unpreserved and not frozen.
Interference
Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.​
Performing Laboratory Information
 
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​

Tuesday, Thursday​

Samples must be in the performing department by 8am on the day of testing for results the same day
6-8 hours​HPLC MS/MS - Applied Biosystems, MDS Sciex, API 3000 MS/MS System.​
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.​
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 69 – 750 ug/g creatinine

Metanephrine: 27 – 270 ug/g creatinine ​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
Synonyms/Keywords
Metanephrine, Normetanephrine; Metanephrines/Creatinine Ratio​
Test Components
Urine Metanephrine, Normetanephrine and Creatinine give a Metanephrine/Creatinine Ratio​
Ordering Applications
Ordering Application Description
​Centricity ​Metanephrine/Creat
​Cerner ​Metanephrine/Creat Rat-Rand Ur
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage cup with 0.1 g sulfamic acid
50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5​
 10 mL​ 5 mL urine​ 5 mL urine​
Collection Processing
Collection instruction: If random specimens are collected unpreserved, specimen must be hand carried to the lab for immediate addition of 0.1 grams of sulfamic acid. If preferred or acceptable container preservatives are unavailable, the unpreserved sample can be immediately frozen and transported frozen to Marshfield labs.
 
Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.
Specimen Stability Information
Specimen Type Temperature Time
Urine​ (preserved) ​ Refrigerate​ 1 week
​Frozen​1 week
​Urine (unpreserved) ​​Refrigerate​48 hours
​Frozen​48 hours
Rejection Criteria
​Specimens that are unpreserved and not frozen.
Interference
Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.​
Useful For

Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as “metanephrines,” together with plasma metanephirne levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.

Test Components
Urine Metanephrine, Normetanephrine and Creatinine give a Metanephrine/Creatinine Ratio​
Reference Range Information
Performing Location Reference Range
Marshfield​

Normetanephrine: 69 – 750 ug/g creatinine

Metanephrine: 27 – 270 ug/g creatinine ​

For more information visit:
Performing Laboratory Information
 
 
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​

Tuesday, Thursday​

Samples must be in the performing department by 8am on the day of testing for results the same day
6-8 hours​HPLC MS/MS - Applied Biosystems, MDS Sciex, API 3000 MS/MS System.​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83835​ ​ ​ ​ ​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
For most current information refer to the Marshfield Laboratory online reference manual.