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22898 Myoglobin, Urine Quantitative

Myoglobin, Urine Quantitative
Test Code: MYO
Synonyms/Keywords
Myo, Urine
Useful For
Myoglobin is used as an indicator of rhabdomyolysis (muscle breakdown) although it is neither sensitive nor specific for this disorder.​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Urine​ Sterile container/cup ​ 5 - 10 mL​ 1.0 mL​ 0.25 mL​
Collection Processing Instructions

Myoglobin is unstable at the native pH of urine even when frozen. Adjust urine to pH 7-9 by addition of sodium hydroxide or sodium carbonate solution. Alternatively, add 8-10 mL of urine to a "Uric Acid Aliquot Tube".  See aliquotting of 24-Hour Urines for Multiple Tests. 
This tube containing dried sodium carbonate when filled with this volume will raise the pH to the desired range. Store refrigerated overnight or freeze for longer storage.

 

Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerated​ 48 hours​
Frozen​ >48 hours​
Interference
Human anti-mouse antibodies (HAMA) may be present in samples from patients who have received immunotherapy utilizing monoclonal antibodies. Additionally, other heterophile antibodies such as human anti-goat antibodies, may be present in patient samples . Carefully evaluate results from patients suspected of having such antibodies.​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Sunday​ 2-4 hours​
Two-site Sandwich Immunoassay using Direct Chemiluminometric Technology/Siemens Centaur ​
Reference Range Information
Performing Location Reference Range
Marshfield​
0 - 500 ng/mL
501 - 15,000 ng/mL associated with vigorous exercise, acute MI, and mild muscle injuries.
>15,000 ng/mL may cause acute renal failure.​
Interpretation
0.5-15.0 mg/L associated with vigorous exercise, acute MI, and mild muscle injuries
>15.0 mg/L may cause acute renal failure​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83874​ ​ ​ ​ ​
Synonyms/Keywords
Myo, Urine
Ordering Applications
Ordering Application Description
​Centricity ​Myoglobin
​Cerner ​Myoglobin, Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Urine​ Sterile container/cup ​ 5 - 10 mL​ 1.0 mL​ 0.25 mL​
Collection Processing

Myoglobin is unstable at the native pH of urine even when frozen. Adjust urine to pH 7-9 by addition of sodium hydroxide or sodium carbonate solution. Alternatively, add 8-10 mL of urine to a "Uric Acid Aliquot Tube".  See aliquotting of 24-Hour Urines for Multiple Tests. 
This tube containing dried sodium carbonate when filled with this volume will raise the pH to the desired range. Store refrigerated overnight or freeze for longer storage.

 

Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerated​ 48 hours​
Frozen​ >48 hours​
Interference
Human anti-mouse antibodies (HAMA) may be present in samples from patients who have received immunotherapy utilizing monoclonal antibodies. Additionally, other heterophile antibodies such as human anti-goat antibodies, may be present in patient samples . Carefully evaluate results from patients suspected of having such antibodies.​
Useful For
Myoglobin is used as an indicator of rhabdomyolysis (muscle breakdown) although it is neither sensitive nor specific for this disorder.​
Reference Range Information
Performing Location Reference Range
Marshfield​
0 - 500 ng/mL
501 - 15,000 ng/mL associated with vigorous exercise, acute MI, and mild muscle injuries.
>15,000 ng/mL may cause acute renal failure.​
Interpretation
0.5-15.0 mg/L associated with vigorous exercise, acute MI, and mild muscle injuries
>15.0 mg/L may cause acute renal failure​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Sunday​ 2-4 hours​
Two-site Sandwich Immunoassay using Direct Chemiluminometric Technology/Siemens Centaur ​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
83874​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.