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22900 Narcolepsy Associated Antigen (NARC)

Narcolepsy Associated Antigen (NARC)
Test Code: NARCAG
Synonyms/Keywords
​Ref Lab Code: 82026, Narcolepsy Associated Ag, B
Useful For
Ruling out a diagnosis of narcolepsy​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole blood​ ​Yellow top (ACD solution B) ​ ​6 mL ​3 mL ​
Collection Processing Instructions
​Do not transfer blood to other containers.
Specimen Stability Information
Specimen Type Temperature
Whole Blood ACD-B​ ​Refrigerated (preferred)
​Ambient
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Friday​ 5 days​
Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probes (SSO)
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)​
Reference Lab
Mayo Clinic Laboratories
Test Information
The DQBeta1*0602 marker is found in virtually all narcoleptics of African Americans, Caucasians, and Japanese however, it must be clearly understood that there are occasional patients who do not have the antigen and that about 25% of normal people have this gene. While DQA1-0102 has also been associated with narcolepsy, no commercial labs offer this testing as it is still a research tool. Additionally, testing for DQB1-0602 is a better test than serologic DR2 testing for narcolepsy risk assessment at this time.
Reference Range Information
Reported as positive or negative for HLA-DQB1*0602.
Almost 100% of narcoleptics are positive; about 25% of normals are positive.
Interpretation
If DQB1*06:02 is not detected, the narcolepsy-associated antigen test result will be reported as negative for DQB1*06:02.
 
If the allele is detected, the result will be reported as positive for DQB1*06:02.
Outreach CPTs
​
CPT Modifier
(if needed)		 Quantity Description Comments
​81376 ​ ​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 82026, Narcolepsy Associated Ag, B
Ordering Applications
Ordering Application Description
​Centricity ​Narcolepsy Assoc Ag
​Cerner Narcolepsy Assoc Ag, Blood (82026)​
​COM ​Narcolepsy Assoc Ag. Blood
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole blood​ ​Yellow top (ACD solution B) ​ ​6 mL ​3 mL ​
Collection Processing
​Do not transfer blood to other containers.
Specimen Stability Information
Specimen Type Temperature
Whole Blood ACD-B​ ​Refrigerated (preferred)
​Ambient
Useful For
Ruling out a diagnosis of narcolepsy​
Reference Range Information
Reported as positive or negative for HLA-DQB1*0602.
Almost 100% of narcoleptics are positive; about 25% of normals are positive.
Interpretation
If DQB1*06:02 is not detected, the narcolepsy-associated antigen test result will be reported as negative for DQB1*06:02.
 
If the allele is detected, the result will be reported as positive for DQB1*06:02.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Friday​ 5 days​
Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probes (SSO)
(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
​
CPT Modifier
(if needed)		 Quantity Description Comments
​81376 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.