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22928 Topiramate, Serum (TOPI)

Topiramate, Serum (TOPI)
Test Code: TOPIRSO
Synonyms/Keywords
Topamax (Topiramate), Topiramate (Topamax)
Useful For
Monitoring serum concentrations of topiramate, particularly in patients with renal disease or those coadministered phenytoin or carbamazepine
 
Assessing compliance
 
Assessing potential toxicity​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​1 mL ​0.4 mL ​
Collection Processing Instructions
​Submit specimen in a plastic vial
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Frozen ​28 days
​Refrigerated (preferred) ​28 days
​Ambient ​28 days
Rejection Criteria
Hemolysis
​Lipemia
​Icterus 
Serum Separator Tube (SST)​ ​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Sunday​ ​Same day/1 day
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
Test Information
​ If dosage and dosing information are provided, they will be included on report to enhance clinical interpretation.
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories
Depends on clinical use:
 
Anticonvulsant: 5.0-20.0 mcg/mL
Psychiatric: 2.0-8.0 mcg/mL
Interpretation
​Most individuals display optimal response to topiramate with serum levels 2.0 mcg/mL to 20.0 mcg/mL. Some individuals may respond well outside of this range, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation.
 
Toxic levels have not been well established.
 
Therapeutic ranges are based on specimens drawn at trough (ie, immediately before the next dose).
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80201 ​ ​ ​ ​
Synonyms/Keywords
Topamax (Topiramate), Topiramate (Topamax)
Ordering Applications
Ordering Application Description
​Centricity ​Topiramate, Serum (81546)
​Cerner ​Topiramate Level (81546)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​1 mL ​0.4 mL ​
Collection Processing
​Submit specimen in a plastic vial
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Frozen ​28 days
​Refrigerated (preferred) ​28 days
​Ambient ​28 days
Rejection Criteria
Hemolysis
​Lipemia
​Icterus 
Serum Separator Tube (SST)​ ​
Useful For
Monitoring serum concentrations of topiramate, particularly in patients with renal disease or those coadministered phenytoin or carbamazepine
 
Assessing compliance
 
Assessing potential toxicity​
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories
Depends on clinical use:
 
Anticonvulsant: 5.0-20.0 mcg/mL
Psychiatric: 2.0-8.0 mcg/mL
Interpretation
​Most individuals display optimal response to topiramate with serum levels 2.0 mcg/mL to 20.0 mcg/mL. Some individuals may respond well outside of this range, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation.
 
Toxic levels have not been well established.
 
Therapeutic ranges are based on specimens drawn at trough (ie, immediately before the next dose).
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Sunday​ ​Same day/1 day
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80201 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.