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22972 Primidone (101)

Primidone (101)
Test Code: PRIMSO
Synonyms/Keywords
Mysoline®​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ 1 mL​ ​0.6 mL ​
​Plasma ​Lithium-heparin Green Top Tube or Sodium-heparin Green Top Tube (GTT) ​ 1 mL​ ​0.6 mL ​
Collection Processing Instructions
Trough levels are most reproducible
Collect specimen just prior to next dose. Half life (adult): 6-8 hours; 70-100 hours (phenobarbital). Time to steady state (adult): 30-40 hours; 15-25 days (phenobarbital). Time to peak level: 2-4 hours. Early in therapy (30 hours) primidone concentration may be in therapeutic range, but phenobarbital (metabolite) may be suboptimal. Call back (total): >15 ug/mL.​
Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma ​ Ambient temperature is acceptable for shipping and/or short-term storage ​ 3 days​
 Specimen may also be refrigerated or frozen for longer storage​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Medtox Laboratories​ performed daily​ 1 day​
Immunoassay (IA)​
Reference Lab
Medtox Laboratories
Test Information
Collect specimen just prior to next dose. Half life (adult): 6-8 hours; 70-100 hours (phenobarbital). Time to steady state (adult): 30-40 hours; 15-25 days (phenobarbital). Time to peak level: 2-4 hours. Early in therapy (30 hours) primidone concentration may be in therapeutic range, but phenobarbital (metabolite) may be suboptimal. Call back (total): >15 ug/mL.​
Reference Range Information
Performing Location Reference Range
Medtox Laboratories​
Report Limit
0.3 ug/ml
Reference Range
5.0 - 12.0 ug/ml
Critical Value - High
15.0 ug/ml​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80188 ​ ​ ​ ​
Synonyms/Keywords
Mysoline®​
Ordering Applications
Ordering Application Description
​Centricity ​Primidone (Mysoline)
​Cerner ​Primidone Level (101)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ 1 mL​ ​0.6 mL ​
​Plasma ​Lithium-heparin Green Top Tube or Sodium-heparin Green Top Tube (GTT) ​ 1 mL​ ​0.6 mL ​
Collection Processing
Trough levels are most reproducible
Collect specimen just prior to next dose. Half life (adult): 6-8 hours; 70-100 hours (phenobarbital). Time to steady state (adult): 30-40 hours; 15-25 days (phenobarbital). Time to peak level: 2-4 hours. Early in therapy (30 hours) primidone concentration may be in therapeutic range, but phenobarbital (metabolite) may be suboptimal. Call back (total): >15 ug/mL.​
Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma ​ Ambient temperature is acceptable for shipping and/or short-term storage ​ 3 days​
 Specimen may also be refrigerated or frozen for longer storage​
Reference Range Information
Performing Location Reference Range
Medtox Laboratories​
Report Limit
0.3 ug/ml
Reference Range
5.0 - 12.0 ug/ml
Critical Value - High
15.0 ug/ml​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Medtox Laboratories​ performed daily​ 1 day​
Immunoassay (IA)​
Reference Lab
Medtox Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80188 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.