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22973 Procainamide and NAPA (PA)

Procainamide and NAPA (PA)
Test Code: PROCSO
Synonyms/Keywords
​Ref Lab Code: 8683, Procainamide, NAPA, Pronestyl, N-Acetyl Procainamide
Test Components
​N-Acetyl Procainamide, N-acetylprocainamide
Useful For
Quantitative measurement for monitoring therapy, assessing compliance or evaluating toxicity.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.5 mL ​0.25 mL ​
Collection Processing Instructions
​Serum separator tubes should be centrifuged within 2 hours of collection.  Red top tubes should be centrifuged and aliquoted within 2 hours of collection.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerated ​7 days
​Ambient ​24 hours
​Frozen (preferred) ​14 days
Rejection Criteria
​Gross Hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Saturday​ ​Same day/1 day
Homogeneous Enzyme Immunoassay Technique
Includes a separate determiniation of N-acetylprocainamide (NAPA)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
PROCAINAMIDE
Therapeutic concentration: 4.0-10.0 mcg/mL
Critical value: >12.0 mcg/mL
 
N-ACETYLPROCAINAMIDE
Therapeutic concentration: 12.0-18.0 mcg/mL
Critical value: > or =40.0 mcg/mL
Interpretation
​Administration of a dose of 50 mg/kg will usually yield the optimal trough concentration in the range of 4.0 to 10.0 mcg/mL for procainamide and 12.0 to 18.0 mcg/mL for N-acetylprocainamide. 
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80192 ​ ​1 ​
Synonyms/Keywords
​Ref Lab Code: 8683, Procainamide, NAPA, Pronestyl, N-Acetyl Procainamide
Test Components
​N-Acetyl Procainamide, N-acetylprocainamide
Ordering Applications
Ordering Application Description
​Centricity ​Procainamide-includes NAPA (PA)
​Cerner ​Procainamide/NAPA Levels (PA)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.5 mL ​0.25 mL ​
Collection Processing
​Serum separator tubes should be centrifuged within 2 hours of collection.  Red top tubes should be centrifuged and aliquoted within 2 hours of collection.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerated ​7 days
​Ambient ​24 hours
​Frozen (preferred) ​14 days
Rejection Criteria
​Gross Hemolysis
Useful For
Quantitative measurement for monitoring therapy, assessing compliance or evaluating toxicity.
Test Components
​N-Acetyl Procainamide, N-acetylprocainamide
Reference Range Information
PROCAINAMIDE
Therapeutic concentration: 4.0-10.0 mcg/mL
Critical value: >12.0 mcg/mL
 
N-ACETYLPROCAINAMIDE
Therapeutic concentration: 12.0-18.0 mcg/mL
Critical value: > or =40.0 mcg/mL
Interpretation
​Administration of a dose of 50 mg/kg will usually yield the optimal trough concentration in the range of 4.0 to 10.0 mcg/mL for procainamide and 12.0 to 18.0 mcg/mL for N-acetylprocainamide. 
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Monday through Saturday​ ​Same day/1 day
Homogeneous Enzyme Immunoassay Technique
Includes a separate determiniation of N-acetylprocainamide (NAPA)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80192 ​ ​1 ​
For most current information refer to the Marshfield Laboratory online reference manual.