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22984 Protein S Activity (Functional)

Protein S Activity (Functional)
Test Code: PROTSF
Synonyms/Keywords
Protein S, Functional​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ 0.75 mL​ 0.75 mL​ 0.5 mL​
Collection Processing Instructions
One 0.75 mL citrated Blue Top Tube (BTT) plasma aliquot.
If more than one coagulation test is ordered, a separate aliquot is needed for each test.
-Collect in Citrated Blue Top Tube (BTT)
-Citrate anticoagulant must be adjusted for HCT >55%
-Tube must be at least 90% full
-Invert completely 3-4 times (without shaking) to mix
*See Instructions for: Preparation of Platelet Poor Plasma)
Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Weekly ​Less than 2 hours Optical clot detection /Siemens BCSXP​
Test Information
Do not order if the patient has received Coumadin for the past two weeks. If patient is on a stable dose of Coumadin (2 weeks), see Protein S Antigen, On Coumadin test (PROT-SM).
See Clinical Practice Guidelines for more information​
Reference Range Information
Performing Location Reference Range
Marshfield​ 72-154% ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​85306 ​ ​ ​
Synonyms/Keywords
Protein S, Functional​
Ordering Applications
Ordering Application Description
​Centricity ​Protein S Activity
​Cerner ​Protein S Activity or Functional
​COM ​Protein S Ag-ON Coumadin
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
*Platelet Poor Plasma 3.2% Citrated Blue Top Tube (BTT)​ ​ 0.75 mL​ 0.75 mL​ 0.5 mL​
Collection Processing
One 0.75 mL citrated Blue Top Tube (BTT) plasma aliquot.
If more than one coagulation test is ordered, a separate aliquot is needed for each test.
-Collect in Citrated Blue Top Tube (BTT)
-Citrate anticoagulant must be adjusted for HCT >55%
-Tube must be at least 90% full
-Invert completely 3-4 times (without shaking) to mix
*See Instructions for: Preparation of Platelet Poor Plasma)
Specimen Stability Information
Specimen Type Temperature Time
​Plasma ​Frozen ​6 months
Rejection Criteria
Clotted or Hemolyzed
​Contamination with IV or Hickman Line fluids
​Specimens that thaw during storage or transport
Reference Range Information
Performing Location Reference Range
Marshfield​ 72-154% ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Weekly ​Less than 2 hours Optical clot detection /Siemens BCSXP​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​85306 ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.