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23058 Surgical Pathology, HPV DNA ISH (HPVHL)

Surgical Pathology, HPV DNA ISH (HPVHL)
Test Code: HPVDNSO
Synonyms/Keywords
HPV DNA ISH
HPV LR/HR
HPVI
Test Components
Human Papillomavirus (HPV) Typing, DNA ISH
Human papillomavirus (HPV) high-risk E6/E7 will be performed at the discretion of the Mayo pathologist.
Useful For
Detection of both low-risk (6, 11) and high-risk genotypes (16, 18, 31, 33, and 51) of human papillomavirus DNA in paraffin-embedded human tissue.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Formalin-fixed, paraffin-embedded tissue block ​ ​ ​Entire block ​
​6 unstained glass, positively charged slides with 5 (+ or - 1)-microns formalin-fixed, paraffin-embedded tissue ​ ​ ​6 slides ​ ​
Collection Processing Instructions
A pathology/diagnostic report and a brief history are required.
Acceptable Specimen Types
​10% neutral buffered formalin fixed tissue specimen/ paraffin embedded tissue block
Specimen Stability Information
Specimen Type Temperature Time
​Tissue Slides Ambient ​ Indefinite
​10% Neutral Buffered Formalin Fixed Tissue Specimen ​ Ambient (preferred) ​ 6 months
​Refrigerate ​1 month
Rejection Criteria
Wet/Frozen Tissue
​Cytology Smears
​Nonformalin fixed tissue
​Nonparaffin embedded tissue
​Noncharged slides
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday - Friday ​5 days In situ hybridization on sections of paraffin-embedded tissue.(Unpublished Mayo method)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​Interpretive report.
Results are reported as positive or negative for low-risk genotypes 6, 11, and/or high-risk genotypes 16, 18, 31, 33, and 51. If additional interpretation or analysis is needed, request 70012 / Pathology Consultation along with this test.
Interpretation
This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation or analysis is needed, request 70012 / Pathology Consultation along with this test.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
88365 ​ ​1 ​Human Papillomavirus Typing In Situ ​
​88364 ​ ​1 ​Insitu Hybridization (FISH) ​
Synonyms/Keywords
HPV DNA ISH
HPV LR/HR
HPVI
Test Components
Human Papillomavirus (HPV) Typing, DNA ISH
Human papillomavirus (HPV) high-risk E6/E7 will be performed at the discretion of the Mayo pathologist.
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Formalin-fixed, paraffin-embedded tissue block ​ ​ ​Entire block ​
​6 unstained glass, positively charged slides with 5 (+ or - 1)-microns formalin-fixed, paraffin-embedded tissue ​ ​ ​6 slides ​ ​
Collection Processing
A pathology/diagnostic report and a brief history are required.
Acceptable Specimen Types
​10% neutral buffered formalin fixed tissue specimen/ paraffin embedded tissue block
Specimen Stability Information
Specimen Type Temperature Time
​Tissue Slides Ambient ​ Indefinite
​10% Neutral Buffered Formalin Fixed Tissue Specimen ​ Ambient (preferred) ​ 6 months
​Refrigerate ​1 month
Rejection Criteria
Wet/Frozen Tissue
​Cytology Smears
​Nonformalin fixed tissue
​Nonparaffin embedded tissue
​Noncharged slides
Useful For
Detection of both low-risk (6, 11) and high-risk genotypes (16, 18, 31, 33, and 51) of human papillomavirus DNA in paraffin-embedded human tissue.
Test Components
Human Papillomavirus (HPV) Typing, DNA ISH
Human papillomavirus (HPV) high-risk E6/E7 will be performed at the discretion of the Mayo pathologist.
Reference Range Information
Performing Location Reference Range
​Mayo Medical Laboratories ​Interpretive report.
Results are reported as positive or negative for low-risk genotypes 6, 11, and/or high-risk genotypes 16, 18, 31, 33, and 51. If additional interpretation or analysis is needed, request 70012 / Pathology Consultation along with this test.
Interpretation
This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation or analysis is needed, request 70012 / Pathology Consultation along with this test.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories ​Monday - Friday ​5 days In situ hybridization on sections of paraffin-embedded tissue.(Unpublished Mayo method)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
88365 ​ ​1 ​Human Papillomavirus Typing In Situ ​
​88364 ​ ​1 ​Insitu Hybridization (FISH) ​
For most current information refer to the Marshfield Laboratory online reference manual.