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Lab Test Reference Manual
Human Reference Manual
Pages
23096
Lab Test Reference Manual
Human Reference Manual
Currently selected
23096
Tryptase, Serum (TRYPT)
Marshfield Lab Public WebSite
Marshfield Clinic Public WebSite
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Site Contents
Tryptase, Serum (TRYPT)
Test Code: TRYPT
Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding
Synonyms/Keywords
Synonyms, Keywords
Ref Lab Code: 81608, Mast Cell Tryptase
Useful For
Useful For
Assessing mast cell activation, which may occur as a result of anaphylaxis or allergen challenge
Assessing patients with systemic mastocytosis or mast cell activation syndrome
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum
Red Top Tube (RTT)
Serum Separator Tube (SST)
0.5 mL
0.2 mL
Collection Processing Instructions
Collection Processing
Send specimen in a plastic vial
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Serum
Frozen (preferred)
14 days
Refrigerated
14 days
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Mayo Medical Laboratories
Monday through Friday
1 day
Fluorescence Enzyme Immunoassay (FEIA)
Reference Lab
Mayo Clinic Laboratories
Test Information
Test Information
Tryptase, a neutral protease, is a dominant protein component of the secretory granules of human mast cells. There are 2 forms of tryptase, designated as alpha and beta, which are encoded by 2 separate genes. Both are expressed as inactive proenzymes. Alpha-protryptase and beta-protryptase are spontaneously released from resting mast cells. The levels of the protrypases reflect the total number of mass cells within the body, but are not an indication of mast cell activation. Beta-protryptase is processed to a mature form, which is stored in granules and released as an active tetramer that is bound to heparin or chondroitin sulfate proteoglycans. In contrast, an amino acid change in alpha-protryptase prevents processing to a mature form. Upon mast cell activation, degranulation releases mature tryptase, which is almost exclusively in the form of beta-tryptase.
After anaphylaxis, mast cell granules release tryptase; measurable amounts are found in blood, generally within 30 to 60 minutes. The levels decline under first-order kinetics with half-life of approximately 2 hours. By comparison, histamine (another immunologic mediator released by activated mast cells) is cleared from blood within minutes. Increased serum levels may also occur after allergen challenge or in patients with systemic mastocytosis or mast cell activation syndrome.
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Mayo Medical Laboratories
<11.5 ng/mL
Interpretation
Interpretations
Levels of total tryptase in serum > or =11.5 ng/mL may indicate mast cell activation occurring as a result of anaphylaxis or allergen challenge, or it may indicate increased number of mast cells as seen in patients with mastocytosis.
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
83520
Synonyms/Keywords
Synonyms, Keywords
Ref Lab Code: 81608, Mast Cell Tryptase
Ordering Applications
Ordering Applications
Ordering Application
Description
Centricity
Tryptase
Cerner
Tryptase (81608)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum
Red Top Tube (RTT)
Serum Separator Tube (SST)
0.5 mL
0.2 mL
Collection Processing
Collection Processing
Send specimen in a plastic vial
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Serum
Frozen (preferred)
14 days
Refrigerated
14 days
Useful For
Useful For
Assessing mast cell activation, which may occur as a result of anaphylaxis or allergen challenge
Assessing patients with systemic mastocytosis or mast cell activation syndrome
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Mayo Medical Laboratories
<11.5 ng/mL
Interpretation
Interpretations
Levels of total tryptase in serum > or =11.5 ng/mL may indicate mast cell activation occurring as a result of anaphylaxis or allergen challenge, or it may indicate increased number of mast cells as seen in patients with mastocytosis.
For more information visit:
http://labtestsonline.org
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Mayo Medical Laboratories
Monday through Friday
1 day
Fluorescence Enzyme Immunoassay (FEIA)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
83520
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For most current information refer to the Marshfield Laboratory online reference manual.