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23149 Digoxin, Unbound, Serum or Plasma (191)

Digoxin, Unbound, Serum or Plasma (191)
Test Code: MISC
Synonyms/Keywords
Digibind®; Lanoxicaps®; Lanoxin®, Digoxin, Free, Free Digoxin​
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​3 mL ​1 mL ​
​Plasma ​Lithium-heparin Green Top Tube of Sodium-heparin Green Top Tube (GTT) ​ ​3 mL ​1 mL ​
Collection Processing Instructions

​Trough levels are most reproducible; minimum of 6 hours post dose.

This test should be ordered when Digibind, a drug that is indicated for treatment of potentially life-threatening digoxin intoxication, has been administered.

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma​
Ambient temperature is acceptable for shipping and/or short-term storage
​3 days
Specimen may also be refrigerated or frozen for longer storage.​
Rejection Criteria
Serum Separator Tube (SST) Not Acceptable
​Plasma Separator Tube (PST) ​Not Acceptable
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Medtox Laboratories​ Performed daily​ ​1-2 days
Ultrafiltration; Immunoassay (IA)
Reference Lab
Medtox Laboratories
Test Information
This test should be ordered when Digibind, a drug that is indicated for treatment of potentially life-threatening digoxin intoxication, has been administered.​
Reference Range Information
Reference Range
Digoxin, Unbound, ng/ml
Report Limit
0.2 ng/ml
Reference Range
0.3 - 1.5 ng/ml
Critical Value - High
2.2 ng/ml
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comment​​s
​80163 ​ ​ ​ ​
Synonyms/Keywords
Digibind®; Lanoxicaps®; Lanoxin®, Digoxin, Free, Free Digoxin​
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​ ​3 mL ​1 mL ​
​Plasma ​Lithium-heparin Green Top Tube of Sodium-heparin Green Top Tube (GTT) ​ ​3 mL ​1 mL ​
Collection Processing

​Trough levels are most reproducible; minimum of 6 hours post dose.

This test should be ordered when Digibind, a drug that is indicated for treatment of potentially life-threatening digoxin intoxication, has been administered.

Specimen Stability Information
Specimen Type Temperature Time
​Serum or Plasma​
Ambient temperature is acceptable for shipping and/or short-term storage
​3 days
Specimen may also be refrigerated or frozen for longer storage.​
Rejection Criteria
Serum Separator Tube (SST) Not Acceptable
​Plasma Separator Tube (PST) ​Not Acceptable
Reference Range Information
Reference Range
Digoxin, Unbound, ng/ml
Report Limit
0.2 ng/ml
Reference Range
0.3 - 1.5 ng/ml
Critical Value - High
2.2 ng/ml
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Medtox Laboratories​ Performed daily​ ​1-2 days
Ultrafiltration; Immunoassay (IA)
Reference Lab
Medtox Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comment​​s
​80163 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.