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23205 Oxcarbazepine Metabolite

Oxcarbazepine Metabolite
Test Code: OXCAR
Synonyms/Keywords
Trileptal, Monohydroxycarbamazepine, MHC, 10-hydroxy-10,11 dihydrocarbamazepine​
Useful For
This test is useful for monitoring oxcarbazepine (anticonvulsant) therapy​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum Red Top Tube (RTT)​ 0.5 mL​ 0.5 mL​ 0.3 mL​
Collection Processing Instructions
Indicate collection time.​
Specimen Stability Information
Specimen Type Temperature Time
​ Serum ​Ambient ​48 hrs
Refrigerate​ 2 weeks
Frozen 2 weeks
Rejection Criteria
​​Specimens collected in serum or plasma separator tubes
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday, Wednesday, Friday​ 1 day​
UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System​
Samples must be in performing department by 8am on day of testing for results the same day.​ ​ ​ ​​ ​
Testing may be batched and set up on alternative days of the week as needed.
Reference Range Information
Performing Location Reference Range
Marshfield​

Trough concentration: 6-10 ug/mL

Peak concentration: less than 40 ug/mL

Critical value: See critical value list of current critical values​

Interpretation

Optimal response to oxcarbazepine generally occurs when trough concentration is in the range of 6-10 ug/mL.  Peak concentration should be less than 40 ug/mL.

Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.​

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80183 ​ ​ ​ ​
Synonyms/Keywords
Trileptal, Monohydroxycarbamazepine, MHC, 10-hydroxy-10,11 dihydrocarbamazepine​
Ordering Applications
Ordering Application Description
​Centricity ​Oxcarbazepine Metabolite
​Cerner ​Oxcarbazepine Metabolite
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum Red Top Tube (RTT)​ 0.5 mL​ 0.5 mL​ 0.3 mL​
Collection Processing
Indicate collection time.​
Specimen Stability Information
Specimen Type Temperature Time
​ Serum ​Ambient ​48 hrs
Refrigerate​ 2 weeks
Frozen 2 weeks
Rejection Criteria
​​Specimens collected in serum or plasma separator tubes
Useful For
This test is useful for monitoring oxcarbazepine (anticonvulsant) therapy​
Reference Range Information
Performing Location Reference Range
Marshfield​

Trough concentration: 6-10 ug/mL

Peak concentration: less than 40 ug/mL

Critical value: See critical value list of current critical values​

Interpretation

Optimal response to oxcarbazepine generally occurs when trough concentration is in the range of 6-10 ug/mL.  Peak concentration should be less than 40 ug/mL.

Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.​

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday, Wednesday, Friday​ 1 day​
UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System​
Samples must be in performing department by 8am on day of testing for results the same day.​ ​ ​ ​​ ​
Testing may be batched and set up on alternative days of the week as needed.
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80183 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.