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23422 Manganese, Blood (MNB)

Manganese, Blood (MNB)
Test Code: BMANGSO
Synonyms/Keywords
​Ref Lab Code: 89120
Useful For
Evaluation of central nervous system symptoms similar to Parkinson disease in manganese miners and processors
 
Characterization of liver cirrhosis
 
Therapeutic monitoring in treatment of cirrhosis, parenteral nutrition-related Mn toxicity and environmental exposure to Mn
 
Evaluation of Behcet disease
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole blood​ Royal-blue top (EDTA) Monoject trace element blood collection ​ ​ 0.8 mL​ ​0.2 mL ​
Collection Processing Instructions
​Draw blood in a Royal Blue EDTA trace element tube available from Marshfield Labs. Send the sample in the original container.
Specimen Stability Information
Specimen Type Temperature Time
​Whole blood ​Refrigerated (preferred) 10 days​
​ ​Ambient ​10 days
​ ​Frozen ​10 days
Rejection Criteria
Hemolysis Mild OK; Gross OK
​Lipemia
Mild OK; Gross OK​
​Icterus
Mild OK; Gross OK
​Heparin Green Top Tube (GTT) ​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Friday​ ​1 day
DRC-ICP-MS​
Reference Lab
Mayo Clinic Laboratories
Test Information
Manganese is a trace element that is an essential cofactor for several enzymes, including one form of superoxide dismutase and the gluconeogenic enzymes pyruvate carboxylase and isocitrate dehydrogenase. It circulates in the serum as a metalloprotein complex with any of several proteins. The +2 and +3 states are of biological significance, but speciation in the analysis has not been studied sufficiently to determine its value. The required daily intake of 1 mg to 6 mg is readily supplied by a normal diet with a diverse mixture of fruits and vegetables.
 
Manganese ores and alloys are refined and used in the making of batteries, welding rods, and high-temperature refractory materials. Environmental exposure occurs from inhalation and ingestion of manganese-containing dust and fumes occurring from the refinement processes. It is likely that inhaled Mn is mobilized up the trachea and swallowed; uptake through the gut is inefficient, about 10%.
 
The major compartment for circulating Mn is the erythrocytes, bound to hemoglobin, with whole blood concentrations of Mn (in normals) being 10 times that of the serum. Mn passes from the blood to the tissues quickly. Concentrations in the liver are highest, with 1 mg Mn/kg to 1.5 mg Mn/kg (wet weight) in normal individuals. The half-life of Mn in the body is about 40 days, with elimination primarily through the feces. Only small amounts are excreted in the urine.
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​ ​4.7-18.3 ng/mL
Interpretation
Whole blood levels above the normal range are indicative of manganism. Values between 1 and 2 times the upper limit of normal may be due to differences in hematocrit and normal biological variation, and should be interpreted with caution before concluding that hypermanganesemia is contributing to the disease process. Values greater than twice the upper limit of normal correlate with disease. For longitudinal monitoring, sampling no more frequently than the half-life of the element (40 days) should be used.​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83785 ​ ​ ​ ​
Synonyms/Keywords
​Ref Lab Code: 89120
Ordering Applications
Ordering Application Description
Centricity​ ​Manganese, Blood (89120)
​Cerner None​
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Whole blood​ Royal-blue top (EDTA) Monoject trace element blood collection ​ ​ 0.8 mL​ ​0.2 mL ​
Collection Processing
​Draw blood in a Royal Blue EDTA trace element tube available from Marshfield Labs. Send the sample in the original container.
Specimen Stability Information
Specimen Type Temperature Time
​Whole blood ​Refrigerated (preferred) 10 days​
​ ​Ambient ​10 days
​ ​Frozen ​10 days
Rejection Criteria
Hemolysis Mild OK; Gross OK
​Lipemia
Mild OK; Gross OK​
​Icterus
Mild OK; Gross OK
​Heparin Green Top Tube (GTT) ​
Useful For
Evaluation of central nervous system symptoms similar to Parkinson disease in manganese miners and processors
 
Characterization of liver cirrhosis
 
Therapeutic monitoring in treatment of cirrhosis, parenteral nutrition-related Mn toxicity and environmental exposure to Mn
 
Evaluation of Behcet disease
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​ ​4.7-18.3 ng/mL
Interpretation
Whole blood levels above the normal range are indicative of manganism. Values between 1 and 2 times the upper limit of normal may be due to differences in hematocrit and normal biological variation, and should be interpreted with caution before concluding that hypermanganesemia is contributing to the disease process. Values greater than twice the upper limit of normal correlate with disease. For longitudinal monitoring, sampling no more frequently than the half-life of the element (40 days) should be used.​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Medical Laboratories Friday​ ​1 day
DRC-ICP-MS​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​83785 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.