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24708 TPMT Genetics, Prometheus (3300)

TPMT Genetics, Prometheus (3300)
Test Code: PTPMTSO
Synonyms/Keywords
​TPMT (thiopurine methyltransferase enzyme) Genetics
Useful For
​Prometheus TPMT Genetics helps classify patients as one of three genotypes (homozygous normal, heterozygous, or homozygous recessive). Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT genotype may reduce time to response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Whole Blood ​EDTA Lavender Top Tube (LTT) ​ ​5 mL ​2 mL ​
Collection Processing Instructions
​Minimum specimen volume may vary with the WBC count. If low, submit 5 mL EDTA whole blood
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​ ​Ambient ​10 days
​Refrigerated ​30 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Prometheus Labs ​Monday through Friday ​2-4 days ​Nucleic acid probe
Reference Lab
Prometheus Biosciences
Reference Range Information
Performing Location Reference Range
Prometheus Labs​ ​TPMT*1/TPMT*1 - Alleles present are associated with Normal Enzyme Activity.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81335 ​ ​ ​ ​
Synonyms/Keywords
​TPMT (thiopurine methyltransferase enzyme) Genetics
Ordering Applications
Ordering Application Description
​Centricity ​TPMT Genetics, Prometheus (3300)
​Cerner ​TPMT Genetics, Prometheus (3300)
​COM ​TPMT Genetics, Prome (3300)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Whole Blood ​EDTA Lavender Top Tube (LTT) ​ ​5 mL ​2 mL ​
Collection Processing
​Minimum specimen volume may vary with the WBC count. If low, submit 5 mL EDTA whole blood
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​ ​Ambient ​10 days
​Refrigerated ​30 days
Useful For
​Prometheus TPMT Genetics helps classify patients as one of three genotypes (homozygous normal, heterozygous, or homozygous recessive). Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT genotype may reduce time to response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia.
Reference Range Information
Performing Location Reference Range
Prometheus Labs​ ​TPMT*1/TPMT*1 - Alleles present are associated with Normal Enzyme Activity.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Prometheus Labs ​Monday through Friday ​2-4 days ​Nucleic acid probe
Reference Lab
Prometheus Biosciences
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​81335 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.