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Lab Test Reference Manual
Human Reference Manual
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TPMT Genetics, Prometheus (3300)
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Site Contents
TPMT Genetics, Prometheus (3300)
Test Code: PTPMTSO
Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding
Synonyms/Keywords
Synonyms, Keywords
TPMT (thiopurine methyltransferase enzyme) Genetics
Useful For
Useful For
Prometheus TPMT Genetics helps classify patients as one of three genotypes (homozygous normal, heterozygous, or homozygous recessive). Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT genotype may reduce time to response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia.
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Whole Blood
EDTA Lavender Top Tube (LTT)
5 mL
2 mL
Collection Processing Instructions
Collection Processing
Minimum specimen volume may vary with the WBC count. If low, submit 5 mL EDTA whole blood
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Whole Blood
Ambient
10 days
Refrigerated
30 days
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Prometheus Labs
Monday through Friday
2-4 days
Nucleic acid probe
Reference Lab
Prometheus Biosciences
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Prometheus Labs
TPMT*1/TPMT*1 - Alleles present are associated with Normal Enzyme Activity.
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
81335
Synonyms/Keywords
Synonyms, Keywords
TPMT (thiopurine methyltransferase enzyme) Genetics
Ordering Applications
Ordering Applications
Ordering Application
Description
Centricity
TPMT Genetics, Prometheus (3300)
Cerner
TPMT Genetics, Prometheus (3300)
COM
TPMT Genetics, Prome (3300)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Whole Blood
EDTA Lavender Top Tube (LTT)
5 mL
2 mL
Collection Processing
Collection Processing
Minimum specimen volume may vary with the WBC count. If low, submit 5 mL EDTA whole blood
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Whole Blood
Ambient
10 days
Refrigerated
30 days
Useful For
Useful For
Prometheus TPMT Genetics helps classify patients as one of three genotypes (homozygous normal, heterozygous, or homozygous recessive). Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT genotype may reduce time to response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia.
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Prometheus Labs
TPMT*1/TPMT*1 - Alleles present are associated with Normal Enzyme Activity.
For more information visit:
http://labtestsonline.org
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Prometheus Labs
Monday through Friday
2-4 days
Nucleic acid probe
Reference Lab
Prometheus Biosciences
For billing questions, see Contacts
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
81335
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For most current information refer to the Marshfield Laboratory online reference manual.