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24961 Amikacin, Random, S (RAMIK)

Amikacin, Random, S (RAMIK)
Test Code: AMIKASO
Synonyms/Keywords
Amikacin Sulfate (Amikin)
Amikacin, Random, S
Amikin (Amikacin Sulfate)
Antibiotic Assay
Antimicrobial Assay
Useful For
​Monitoring adequacy of blood concentration during amikacin therapy
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Serum Separator Tube (SST) ​Red Top Tube (RTT) 0.5 mL​ ​0.25 mL ​
Collection Processing Instructions
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.
Additional Information: Serum for a peak level should be drawn 30 to 60 minutes after last dose (order PAMIK / Amikacin, Peak, Serum). Serum for a trough level should be drawn immediately before next scheduled dose (order TAMIK / Amikacin, Trough, Serum).
Specimen Stability Information
Specimen Type Temperature Time
​Serum​ Refrigerate (preferred) 14 days
Frozen ​28 days
​Room Temperature ​72 hours
Rejection Criteria
Gross Hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​ Monday through Sunday 1 day​
Kinetic interaction of microparticles in solution (KIMS)
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​
Therapeutic (Peak): 20.0-35.0 ug/mL.
Therapeutic (Trough): < 8.0 ug/mL.
Toxic (Peak): >40.0 ug/mL.
Toxic (Trough): >10.0 ug/mL.
Interpretation
For conventional (nonpulse) dosing protocols, clinical effects may not be achieved if the peak serum concentration is <20.0 mcg/mL. Toxicity may occur if, for prolonged periods of time, peak serum concentrations are maintained >35.0 mcg/mL, or trough concentrations are maintained at >10.0 mcg/mL.
Aminoglycosides are excreted primarily by glomerular filtration, thus, the serum half-life will be prolonged and significant accumulation will occur in patients with impaired renal function.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80150 ​ ​ ​ ​
Synonyms/Keywords
Amikacin Sulfate (Amikin)
Amikacin, Random, S
Amikin (Amikacin Sulfate)
Antibiotic Assay
Antimicrobial Assay
Ordering Applications
Ordering Application Description
Centricity​ ​Amikacin, Serum
​Cerner ​Amikacin Level (200)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ Serum Separator Tube (SST) ​Red Top Tube (RTT) 0.5 mL​ ​0.25 mL ​
Collection Processing
1. Serum gel tubes should be centrifuged within 2 hours of collection.
2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.
Additional Information: Serum for a peak level should be drawn 30 to 60 minutes after last dose (order PAMIK / Amikacin, Peak, Serum). Serum for a trough level should be drawn immediately before next scheduled dose (order TAMIK / Amikacin, Trough, Serum).
Specimen Stability Information
Specimen Type Temperature Time
​Serum​ Refrigerate (preferred) 14 days
Frozen ​28 days
​Room Temperature ​72 hours
Rejection Criteria
Gross Hemolysis
Useful For
​Monitoring adequacy of blood concentration during amikacin therapy
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​
Therapeutic (Peak): 20.0-35.0 ug/mL.
Therapeutic (Trough): < 8.0 ug/mL.
Toxic (Peak): >40.0 ug/mL.
Toxic (Trough): >10.0 ug/mL.
Interpretation
For conventional (nonpulse) dosing protocols, clinical effects may not be achieved if the peak serum concentration is <20.0 mcg/mL. Toxicity may occur if, for prolonged periods of time, peak serum concentrations are maintained >35.0 mcg/mL, or trough concentrations are maintained at >10.0 mcg/mL.
Aminoglycosides are excreted primarily by glomerular filtration, thus, the serum half-life will be prolonged and significant accumulation will occur in patients with impaired renal function.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​ Monday through Sunday 1 day​
Kinetic interaction of microparticles in solution (KIMS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80150 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.