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25001 Lacosamide (LACO)

Lacosamide (LACO)
Test Code: LACOSO
Synonyms/Keywords
​Vimpat
Useful For
​Monitoring serum concentrations of lacosamide to ensure compliance, and appropriate dosing in specific clinical conditions (ie, severe renal impairment, mild to moderate hepatic impairment, and end-stage renal disease)
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.2 mL ​
Collection Processing Instructions
1.  Draw specimen immediately before next scheduled dose.
2.  For sustained-release formulation ONLY, draw blood a minimum of 12 hours after last dose.
3.  Centrifuge and separate serum from cells or gel within 2 hours of draw.
 
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​ Refrigerated (preferred) ​ 28 days​
​Ambient ​28 days
​Frozen ​28 days
Rejection Criteria
​
Hemolysis
Mild OK; Gross OK
​Lipemia
Mild OK; Gross OK
​Icterus ​Mild OK; Gross OK
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​ Monday through Friday, Saturday Same day/1day
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​
Patients receiving therapeutic doses usually have lacosamide concentrations of 1.0-10.0 mcg/mL
Interpretation
​The serum concentration should be interpreted in the context of the patient's clinical response and may provide useful information in patients showing poor response or adverse effects, particularly when lacosamide is coadministered with other anticonvulsant drugs.
 
Toxic ranges are not established.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80235 ​ ​ ​ ​
Synonyms/Keywords
​Vimpat
Ordering Applications
Ordering Application Description
​Centricity ​Lacosamide (777)
​Cerner ​None
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.2 mL ​
Collection Processing
1.  Draw specimen immediately before next scheduled dose.
2.  For sustained-release formulation ONLY, draw blood a minimum of 12 hours after last dose.
3.  Centrifuge and separate serum from cells or gel within 2 hours of draw.
 
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​ Refrigerated (preferred) ​ 28 days​
​Ambient ​28 days
​Frozen ​28 days
Rejection Criteria
​
Hemolysis
Mild OK; Gross OK
​Lipemia
Mild OK; Gross OK
​Icterus ​Mild OK; Gross OK
Useful For
​Monitoring serum concentrations of lacosamide to ensure compliance, and appropriate dosing in specific clinical conditions (ie, severe renal impairment, mild to moderate hepatic impairment, and end-stage renal disease)
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories​
Patients receiving therapeutic doses usually have lacosamide concentrations of 1.0-10.0 mcg/mL
Interpretation
​The serum concentration should be interpreted in the context of the patient's clinical response and may provide useful information in patients showing poor response or adverse effects, particularly when lacosamide is coadministered with other anticonvulsant drugs.
 
Toxic ranges are not established.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories​ Monday through Friday, Saturday Same day/1day
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80235 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.