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25238 TPMT Enzyme, Prometheus (3320)

TPMT Enzyme, Prometheus (3320)
Test Code: ENZACSO
Synonyms/Keywords
​ENZACT
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Whole Blood EDTA Lavender Top Tube (LTT)​ ​ ​5.0 mL ​3.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time​
Whole Blood ​ ​Refrigerate ​8 days
​Ambient ​24 hours
Rejection Criteria
Frozen samples
​Samples other than EDTA whole blood
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Prometheus Labs Monday through Friday​ 3 days
Enzymatic and HPLC​
Reference Lab
Prometheus Biosciences
Test Information
​TPMT enzyme testing provides a qualitative analysis of patient's thiopurine methyltransferase (TPMT) enzyme activity level. Because each patient metabolizes thipurines differently; the efficacy and toxicity can differ from patient to patient. Knowledge of the TPMT phenotype helps reduce response time, allows provider to provide individual dosing and help identify patients where thiopurine treatment should be avoided.
Reference Range Information
Interpretive report
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82542​ ​ ​1 Qnt HPLC for 6-methyl-thiguanine ​
​82657 ​ ​1 ​TPMP Metabolite enzyme activity in peripheral RBC ​
Synonyms/Keywords
​ENZACT
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Whole Blood EDTA Lavender Top Tube (LTT)​ ​ ​5.0 mL ​3.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time​
Whole Blood ​ ​Refrigerate ​8 days
​Ambient ​24 hours
Rejection Criteria
Frozen samples
​Samples other than EDTA whole blood
Reference Range Information
Interpretive report
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Prometheus Labs Monday through Friday​ 3 days
Enzymatic and HPLC​
Reference Lab
Prometheus Biosciences

​Marshfield Labs
1000 North Oak Avenue
Marshfield, WI 54449-5795

Laboratory Reference Services

  • Marshfield Labs Customer Service
    • Toll-free: 800-222-5835
    • Direct Dial: 715-221-6700
    • Internal: ext. 16700
    • Fax: 715-221-6215
    • Email: mlcussev@marshfieldclinic.org
    • Web Portal Helpline (technical support):866-522-2611

Billing Questions

  • Marshfield Center Patient Assistance Center (PAC)
    • Fee estimates, assistance with available government programs (e.g Badger Care): 800-782-8581 ext. 94475
    • Insurance eligibility, insurance referrals, managed care requirements that include Preadmission Review (PAR): 800-782-8581 ext. 75559
  • Patient Financial Services (PFS)
    • Marshfield Center: Billing statements(questions/concerns): 800-782-8581 ext. 90700
    • Marshfield Labs Billing Department: Billing statements, insurance eligibility/contracts, fee estimates (Non-Sendouts), credit card payments: 800-782-8581 ext. 90616
    • St. Joseph's Hospital of Marshfield (a Ministry affiliate): Internal ext. 77164
For sites other than Marshfield Center, please contact your local PAC (e.g. Diagnostic &Treatment Center, Flambeau Hospital, Lakeview Medical Center)

Toxicology Services

  • Toll-free: 800-331-3734
  • Direct Dial: 715-389-3734
  • Fax: 715-389-3737
  • Billing questions: 715-389-0616
  • Customer Service Email: forensic.toxicology@marshfieldclinic.org
  • Web Portal Helpline (technical support): 866-522-2611

For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82542​ ​ ​1 Qnt HPLC for 6-methyl-thiguanine ​
​82657 ​ ​1 ​TPMP Metabolite enzyme activity in peripheral RBC ​
For most current information refer to the Marshfield Laboratory online reference manual. Fri Mar 14 2025 11:22:55 GMT+0000 (Coordinated Universal Time)